Global Gene Expression Profiling of Human Osteosarcomas Reveals Metastasis-Associated Chemokine Pattern
| Autor: | Gunnar Sæter, Ola Myklebost, Jørn Henriksen, Vidar M. Steen, Stine H. Kresse, Øyvind S. Bruland, Rita Holdhus, Bodil Bjerkehagen, Heidi M. Namløs, Christoph R. Müller |
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| Rok vydání: | 2012 |
| Předmět: |
Chemokine
Article Subject biology business.industry medicine.medical_treatment lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Bioinformatics lcsh:RC254-282 CXCR4 Targeted therapy Metastasis Gene expression profiling Oncology Gene expression medicine biology.protein Cancer research Osteosarcoma Radiology Nuclear Medicine and imaging business Gene Research Article |
| Zdroj: | Sarcoma, Vol 2012 (2012) Sarcoma |
| ISSN: | 1369-1643 1357-714X |
| DOI: | 10.1155/2012/639038 |
| Popis: | Global gene expression analysis was performed on a panel of 23 osteosarcoma samples of primary and metastatic origin using the Applied Biosystems Gene Expression Array System. When comparing the primary tumours with the metastases, we found a significantly increased expression of genes involved in immunological processes, for example coding for cytokines and chemokines, in the metastatic samples. In addition, a comparison of the gene expression in primary samples from patients with or without metastases demonstrated that patients who later developed metastases had high expression of the chemokine (C-X-C motif) receptor 4 (CXCR4), similar to the metastatic samples, suggesting that these signal molecules play an important role in promoting metastasis. Increased knowledge of mechanisms and interactions between specified molecular signalling pathways in osteosarcomas could lead to a more rational strategy for development of targeted therapy. |
| Databáze: | OpenAIRE |
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