In vitro antiplasmodial activity of crude extracts from Togolese medicinal plants
| Autor: | Kouami Kokou, Comlan de Souza, Kodjo Essien, Jacques Simpore, Kodjo Aklikokou, D. Ilboudo, Mensavi Gbeassor, Simplice D. Karou, Koffi Koudouvo |
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| Rok vydání: | 2011 |
| Předmět: |
Plasmodium falciparum
Complex Mixtures Antimalarials Inhibitory Concentration 50 Medicinal plants In vitro Parasitic Sensitivity Tests parasitic diseases Animals Humans Malaria Falciparum Pavetta Aqueous extract Folk medicine Medicine(all) Plants Medicinal biology Traditional medicine Plant Extracts fungi food and beverages Opilia General Medicine biology.organism_classification Togo Ethnobotany Screening Ferns |
| Zdroj: | Asian Pacific Journal of Tropical Medicine. 4(2):129-132 |
| ISSN: | 1995-7645 |
| DOI: | 10.1016/s1995-7645(11)60052-7 |
| Popis: | Objective To investigate the antimalarial effect of a few plants in Togo folk medicine. Methods After ethnobotanical survey, Opilia celtidifolia , Pavetta corymbosa (P. corymbosa) and Tamarindus indica (T. indica) were selected for screening. In vitro antimalarial tests were performed on crude extracts against fresh clinical isolates of Plasmodium falciparum using the semi microtest. Results Different IC 50 values of the extracts ranged from 2.042 to 100.000 μg/mL. According to the results, the methanol extract of aerial part of P. corymbosa followed by aqueous extract of fruit of T. indica were the most active (IC 50 of 2.042 and 4.786 μg/mL, respectively). Qualitative test revealed the presence of alkaloids in the leaves of P. corymbosa that may be responsible for the activity of the plant. Conclusions Our study provides scientific evidence for usage of plant in the folk medicine, and further studies are needed for identification and purification of the active principles. |
| Databáze: | OpenAIRE |
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