Effects of a 6-Month Multifaceted Diet and Exercise Intervention on Cognition in Older Adults at Risk of Cognitive Decline: The PONDER Double-Blind, Placebo-Controlled Randomized Trial

Autor:	Helen Macpherson, Sarah Brownell, Elizabeth Harris, Rachel L. Duckham, Stella O’Connell, Barbara J. Meyer, Sam Mirzaee, Robin M. Daly
Rok vydání:	2022
Předmět:	Male Memory Disorders General Neuroscience Vitamins General Medicine Diet Exercise Therapy Psychiatry and Mental health Clinical Psychology Cognition Double-Blind Method Dietary Supplements Fatty Acids Omega-3 Humans Cognitive Dysfunction Female Vitamin D Geriatrics and Gerontology Aged
Zdroj:	Journal of Alzheimer's Disease. 89:247-263
ISSN:	1875-8908 1387-2877
DOI:	10.3233/jad-220234
Popis:	Background: Multidomain interventions which incorporate exercise and dietary supplementation to target both cognitive and physical health domains may be an important approach to delay cognitive decline. Objective: The Protein Omega-3 aNd vitamin D Exercise Research (PONDER) study investigated the effects of a 6-month multifaceted intervention in community-dwelling older adults with subjective memory impairment on cognition (primary outcome), physical function, and body composition with a further 6-month follow up for cognition (secondary outcomes). Methods: Single-center, community-based, parallel-group, randomized, double-blind placebo-controlled trial involving a 6-month multifaceted intervention with a further follow-up at 12 months. A total of 147 participants [mean age 70.2 years (SD 6.1), 70% female] were randomized to a multimodal exercise program consisting of twice-weekly supervised resistance and aerobic training, combined with a daily omega-3 (900 mg EPA, 600 mg DHA), vitamin D (1000 IU) and protein (20 g) supplement (n = 73), or a control condition (n = 74) comprising stretching/flexibility sessions combined with a placebo. The primary outcome was a composite CogState measure and Trail-Making Test B-A. Results: There were no significant between-group differences in the change of cognition at 6 or 12 months or physical function outcomes at 6 months, but the intervention significantly improved total lean mass compared to controls [0.72 kg (95% CI 0.26–1.19), p = 0.001]. Conclusion: A multi-faceted intervention including an omega-3, vitamin D and protein-enriched supplement with twice-weekly exercise training did not provide any benefits to cognitive or physical function in older adults with subjective memory impairment, despite improvements in lean mass.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd545f5f03d9f6d5cc8d943300d5d9cd https://doi.org/10.3233/jad-220234 Zobrazit plný text záznamu