Degradative and mechanical properties of a novel resorbable plating system during a 3-year follow-up in vivo and in vitro
| Autor: | Ilkka Kallela, Heikki Kainulainen, Immo Rantala, Erkki Wuolijoki, Ilmari Hiidenheimo, Tuomo Nieminen, Jaakko Keranen |
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| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Materials science Time Factors medicine.medical_treatment Bone Screws Biomedical Engineering Biophysics Bioengineering Osteotomy Biomaterials chemistry.chemical_compound In vivo Plating Mandibular Fractures Tensile Strength Ultimate tensile strength Absorbable Implants Materials Testing medicine Shear strength Animals Sheep Mandible Bone fracture medicine.disease Elasticity Internal Fixators Surgery chemistry Female Stress Mechanical Trimethylene carbonate Shear Strength Bone Plates Biomedical engineering Follow-Up Studies |
| Zdroj: | Journal of materials science. Materials in medicine. 19(3) |
| ISSN: | 0957-4530 |
| Popis: | We tested the tissue reactions and mechanical strength of a novel biodegradable craniomaxillofacial plating system, Inion CPS™, in the course of degradation. Plates and screws composed of l-lactide, d-lactide and trimethylene carbonate were implanted to the mandible and dorsal subcutis of 12 sheep. The animals were sacrificed at 6–156 weeks. Histological evaluation was done using paraffin and methylmetacrylate techniques. Degradative and mechanical properties during the follow-up were measured both of in vivo and in vitro implants. In light microscopy, the in vivo implant material began to fragment at 52 weeks and could not be detected at 104 weeks. No significant foreign body reactions were seen in the mandibles. The dorsal subcutis disclosed mild reactions, which were, however, not of clinical significance. The implants in vitro maintained their entire mass for 26 weeks and lost 63–80% of the mass by week 104. The inherent viscosity of the implants in vitro and in vivo diminished uniformly. The screws retained their shear strength for 12–16 weeks. The plates maintained their tensile strength for at least 6 weeks. The maximum capacity of the plates in 3-point bending tests diminished gradually by 87% in 26 weeks. In conclusion, the plates and screws examined maintain adequate strength for the healing period of a bone fracture or osteotomy, producing no harmful foreign body reactions. |
| Databáze: | OpenAIRE |
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