Effect of Natural Cytokine Complex on the Structure and Metabolism of the Cardiac Conduction System in the Myocardium under Normally and Increased Hemodynamic Load

Autor: V. V. Sukhoparova, M. S. Tverskaya, L. V. Gankovskaya, A. O. Virganskii
Rok vydání: 2017
Předmět:
Male
medicine.medical_specialty
medicine.medical_treatment
Heart Ventricles
Citric Acid Cycle
Guinea Pigs
Hemodynamics
Ventricular Septum
030204 cardiovascular system & hematology
General Biochemistry
Genetics and Molecular Biology
Oxidative Phosphorylation
Proinflammatory cytokine
03 medical and health sciences
0302 clinical medicine
Heart Conduction System
Internal medicine
medicine
Animals
Glycolysis
Myocytes
Cardiac
Interventricular septum
Macrophage Migration-Inhibitory Factors
Chemistry
Interleukin-6
Tumor Necrosis Factor-alpha
Myocardium
Arrhythmias
Cardiac
General Medicine
Aortic Valve Stenosis
Myocardial Contraction
medicine.anatomical_structure
Endocrinology
Cytokine
Ventricle
Systemic administration
Cytokines
Interleukin-2
Female
Electrical conduction system of the heart
030217 neurology & neurosurgery
Interleukin-1
Zdroj: Bulletin of experimental biology and medicine. 164(6)
ISSN: 1573-8221
Popis: Effect of natural complex of cytokines with activity of IL-1, IL-2, IL-6, TNF, MIF, and GTFβ on the structure and metabolism of conduction cardiomyocytes was assessed in the control and under acute experimental aortic stenosis. After systemic administration of the cytokine complex in the control, structural abnormalities were revealed in a relatively low number of conduction cardiomyocytes; their relative number increased in the left ventricle and interventricular septum. When the complex was administered against the background of aortic stenosis, morphological changes in the conduction system were seen in a significant number of cells with their plasma imbibition, especially in the left ventricle and interventricular septum. Systemic administration of the natural cytokine complex inhibited the major metabolic processes in the conduction system, both in the control and under conditions of sharply increased hemodynamic load. In conduction cardiomyocytes, deceleration of glycolysis and citric acid cycle, inhibition of oxidation of free fatty acids and their metabolites, and suppression of shuttle mechanisms and biosynthetic reactions were observed. Increased blood levels of cytokines, primarily of the proinflammatory ones, can cause structural and metabolic disturbances in the cardiac conduction system and promote the development of arrhythmias, especially in case of sharply increased hemodynamic load.
Databáze: OpenAIRE
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