Incidence of Hepatocellular Carcinoma in Patients With HCV-Associated Cirrhosis Treated With Direct-Acting Antiviral Agents
| Autor: | A. Licata, Luigi Guarneri, G. Rigano, Carlo Saitta, G. Raimondo, E. Frazzetto, Giuseppe Montalto, S. Maimone, Federica Latteri, I. Scalici, G. Fuduli, A. Craxì, Giuseppe Cabibbo, Anna Licata, C. Cammà, A. Ficalora, F. Di Lorenzo, Marco Distefano, Francesca Savalli, A. Bellia, Giovanni Mazzola, Antonio Magro, Fabio Tinè, M. Distefano, Lydia Giannitrapani, M.R. Alinovi, E. Falzone, F. Tinè, F. Benanti, L.N. Larocca, F. Cartabellotta, G. Cabbibbo, V. Calvaruso, A. Digiacomo, Salvatore Petta, M.A. Di Rosolini, Giuseppe Malizia, Bruno Cacopardo, F. Lomonaco, Vincenza Calvaruso, Marcello Maida, Adriana Sanfilippo, Giuseppa Caccamo, S. Madonia, Giovanni Squadrito, G. Squadrito, Marco Barbara, M. Russello, Gaetano Bertino, L. Larocca, A. Salvo, F. Maffeo, I. Scalisi, G. Scifo, Vito Di Marco, V. Di Marco, L. Giannitrapani, Luigi Mondello, Maria Antonietta Di Rosolini, V. Portelli, A. Smedile, G. Mazzola, Giovanni Raimondo, Antonio Cascio, S. D’Andrea, Carmelo Iacobello, Maurizio Russello, F. Pulvirenti, Antonio Craxì, Calogero Cammà, Salvatore Madonia, A.L. Ardiri, R. Vassallo, R. Benigno, F. Savalli, Alessandro Bellia, T. Prestileo, A. Averna, L. Guarneri, A. Magro, A. Davì, Tullio Prestileo, C. Iacobello, P. Colletti, G. Bertino, Arturo Montineri, Antonio Davì, I. Cacciola, Irene Cacciola, G. Gioia, Giuseppe Alaimo |
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| Přispěvatelé: | Calvaruso, Vincenza, Cabibbo, Giuseppe, Cacciola, Irene, Petta, Salvatore, Madonia, Salvatore, Bellia, Alessandro, Tinè, Fabio, Distefano, Marco, Licata, Anna, Giannitrapani, Lydia, Prestileo, Tullio, Mazzola, Giovanni, Di Rosolini, Maria Antonietta, Larocca, Licia, Bertino, Gaetano, Digiacomo, Antonio, Benanti, Francesco, Guarneri, Luigi, Averna, Alfonso, Iacobello, Carmelo, Magro, Antonio, Scalisi, Ignazio, Cartabellotta, Fabio, Savalli, Francesca, Barbara, Marco, Davì, Antonio, Russello, Maurizio, Scifo, Gaetano, Squadrito, Giovanni, Cammà, Calogero, Raimondo, Giovanni, Craxì, Antonio, Di Marco, Vito, Di Marco, V., Cammà, C., Calvaruso, V., Petta, S., Cabbibbo, G., Colletti, P., Mazzola, G., Cascio, A., Montalto, G., Licata, A., Giannitrapani, L., Prestileo, T., Di Lorenzo, F., Sanfilippo, A., Ficalora, A., Madonia, S., Tinè, F., Malizia, G., Latteri, F., Maida, M., Cartabellotta, F., Vassallo, R., Cacciola, I., Caccamo, G., Maimone, S., Saitta, C., Squadrito, G., Raimondo, G., Mondello, L., Smedile, A., D'Andrea, S., Bertino, G., Ardiri, A.L., Frazzetto, E., Rigano, G., Montineri, A., Larocca, L.N., Cacopardo, B., Benanti, F., Russello, M., Benigno, R., Bellia, A., Iacobello, C., Davì, A., Di Rosolini, M.A., Digiacomo, A., Fuduli, G., Scifo, G., Distefano, M., Portelli, V., Savalli, F., Scalici, I., Gioia, G., Magro, A., Alaimo, G., Alinovi, M.R., Salvo, A., Averna, A., Lomonaco, F., Guarneri, L., Maffeo, F., Falzone, E., Pulvirenti, F. |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Liver Cirrhosis
Male Cirrhosis Settore MED/09 - Medicina Interna Sustained Virologic Response Hepacivirus Gastroenterology 0302 clinical medicine RESIST-HCV Risk Factors Hepatocellular Carcinoma (HCC) Medicine Liver Cancer Risk Prospective Studies Prospective cohort study Settore MED/12 - Gastroenterologia Incidence (epidemiology) Incidence Liver Neoplasms Hepatitis C Middle Aged Direct Antiviral Agents (DAAs) Sustained Virological Response (SVR) hepatitis C Virus (HCV) liver cancer risk reduction sofosbuvir Italy Liver Neoplasm 030220 oncology & carcinogenesis Hepatocellular carcinoma 030211 gastroenterology & hepatology Female Human medicine.medical_specialty Carcinoma Hepatocellular Liver Cirrhosi RESIST-HCV Liver Cancer Risk Reduction Sofosbuvir Antiviral Agents Follow-Up Studie 03 medical and health sciences Internal medicine Humans In patient Aged Reduction Antiviral Agent Hepaciviru Hepatology business.industry Proportional hazards model Risk Factor Hepatitis C Chronic medicine.disease digestive system diseases Prospective Studie Child-Pugh Class B Sofosbuvir business Follow-Up Studies |
| Popis: | Background & Aims: Studies have produced conflicting results of the incidence of hepatocellular carcinoma (HCC) in patients with hepatitis C virus–associated cirrhosis treated with direct-acting antivirals (DAAs). Data from clinics are needed to accurately assess the occurrence rate of HCC in patients with cirrhosis in the real world. Methods: We collected data from a large prospective study of 2,249 consecutive patients (mean age = 65.4 years, 56.9% male) with hepatitis C virus–associated cirrhosis (90.5% with Child-Pugh class A and 9.5% with Child-Pugh class B) treated with DAAs from March 2015 through July 2016 at 22 academic and community liver centers in Sicily, Italy. HCC occurrence was evaluated by Kaplan-Meier curves. Cox regression analysis was used to identify variables associated with HCC development. Results: A sustained virologic response (SVR) was achieved by 2,140 patients (total = 95.2%; 95.9% with Child Pugh class A and 88.3% with Child Pugh class B; P |
| Databáze: | OpenAIRE |
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