Low vs standard calcium dialysate in peritoneal dialysis: differences in treatment, biochemistry and bone histomorphometry. A randomized multicentre study
| Autor: | Carmen Sánchez, Alberto Mate, Eugenia Martínez, Rafael Selgas, Auxiliadora Bajo, Fernando López-Barea, Jesús Sánchez-Cabezudo |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Urology Parathyroid hormone chemistry.chemical_element Calcium Bone and Bones Peritoneal dialysis Bone remodeling Biopsy Humans Medicine Renal osteodystrophy Transplantation medicine.diagnostic_test business.industry Middle Aged medicine.disease Hemodialysis Solutions Surgery ROC Curve chemistry Nephrology Hemodialysis business Peritoneal Dialysis Kidney disease |
| Zdroj: | Nephrology Dialysis Transplantation. 19:1587-1593 |
| ISSN: | 1460-2385 0931-0509 |
| DOI: | 10.1093/ndt/gfh214 |
| Popis: | Background. In patients undergoing peritoneal dialysis (PD), low-calcium dialysate (LCD) has been proposed as the first choice for a better control of renal osteodystrophy. Our aim was to compare the effects on bone metabolism of LCD (calcium: 1.25 mmol/l) with that of a standard calcium dialysate (SCD; calcium: 1.75 mmol/l). Methods. Forty-four PD patients were randomized to receive LCD or continue on SCD for a period of 12 months. Bone biopsies were taken at baseline and at 12 months. Biochemical data and treatment were evaluated every 3 months. Results. Twenty-four patients completed the study. In the SCD group (n ¼ 10), nine out of the 10 patients were initially diagnosed with adynamic bone lesion (ABL). After 1 year, six continued having ABL and three patients moved to highturnover bone lesion (HTBL). The other patient, initially diagnosed with HTBL, changed to ABL. In the LCD group (n ¼ 14), 10 patients were initially diagnosed with ABL. At 1 year, six of them continued having ABL and four patients changed to HTBL. Four patients were initially diagnosed with HTBL and did not change. Comparison between LCD and SCD groups showed an increase in serum parathyroid hormone (PTH) levels starting at month 3 and a higher intake of calcium salts in the former group (P |
| Databáze: | OpenAIRE |
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