Preparation of hemocompatible cellulosic paper based on P(DMAPS)-functionalized surface
| Autor: | Youchao Song, Xiao Jiang, Bingfeng Cai, Xiaofan Zhou, Haolin Zhao, Chun Mao, Ruide Yu, Wenzhi Lv |
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| Rok vydání: | 2013 |
| Předmět: |
Blood Platelets
Paper Erythrocytes Surface Properties Biocompatible Materials chemistry.chemical_compound Colloid and Surface Chemistry Platelet Adhesiveness Polymethacrylic Acids Polymer chemistry medicine Animals Platelet activation Physical and Theoretical Chemistry Particle Size Cellulose Chemistry Atom-transfer radical-polymerization Surfaces and Interfaces General Medicine Adhesion medicine.disease Platelet Activation Hemolysis Quaternary Ammonium Compounds Sulfonate Polymerization Chemical engineering Zwitterion Surface modification Blood Coagulation Tests Rabbits Biotechnology |
| Zdroj: | Colloids and surfaces. B, Biointerfaces. 116 |
| ISSN: | 1873-4367 |
| Popis: | The surface-modification of paper substrates with functional layers is gaining increasing interest, both from academic and industrial research. In this case, the cellulosic paper (CP) surface was functionalized with zwitterionic poly-(3-dimethyl(methacryloyloxyethyl) ammoniumpropane sulfonate) (CP-g-P(DMAPS) via surface-initiated atom transfer radical polymerization (ATRP) technique for enhancing blood compatibility. An obvious increase in graft yield of the functional P(DMAPS) with polymerization time was observed. The new CP-g-P(DMAPS) produced was investigated for its hemocompatibility. The hemocompatibility studied including platelet and whole blood ceels adhesion tests, hemolysis assay, morphological changes of red blood cells (RBCs), coagulation time tests, and complement activation, platelet activation at the molecular level. Most assays had remarkable differences in the presence of the new zwitterionic CP, indicated the importance of the zwitterion for hemocompatibility of CP. |
| Databáze: | OpenAIRE |
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