Time and dose dependency of bone-sarcomas in patients injected with radium-224
| Autor: | H. Spiess, C. E. Land, Albrecht M. Kellerer, C. W. Mays, D. Chmelevsky |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Male Neoplasms Radiation-Induced Time Factors Radium-224 Biophysics Dose dependence Risk Factors Germany High doses Humans Medicine In patient General Environmental Science Osteosarcoma Radiation business.industry Proportional hazards model Low dose Dose-Response Relationship Radiation Risk Estimate Time course Female business Nuclear medicine Mathematics Radium |
| Zdroj: | Radiation and Environmental Biophysics. 27:103-114 |
| ISSN: | 1432-2099 0301-634X |
| DOI: | 10.1007/bf01214600 |
| Popis: | The time course and dose dependency of the incidence of bone-sarcomas among 900 German patients treated with high doses of radium-224 is analysed in terms of a proportional hazards model with a log-normal dependency of time to tumor and a linear-quadratic dose relation. The deduced dose dependency agrees well with a previous analysis in terms of a non-parametric proportional hazards model, and confirms the temporal distribution which has been used in the Radioepidemiological Tables of NIH. However, the linear-quadratic dose-response model gives a risk estimate for low doses which is somewhat less than half that obtained under the assumption of linearity. |
| Databáze: | OpenAIRE |
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