Neuropeptide Y Levels During Ischemia and Reperfusion in the Canine Infrarenal Aortic Revascularization Model
| Autor: | Peter S. Dovgan, Thomas E. Adrian, Jane M. Rowley, John D. Edwards, Patricia E. Thorpe, Devendra K. Agrawal |
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| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Time Factors medicine.medical_treatment Radioimmunoassay Ischemia Hindlimb Revascularization Iliac Artery Constriction Norepinephrine (medication) Dogs Internal medicine mental disorders Animals Medicine Neuropeptide Y Aorta Abdominal Iliac artery business.industry General Medicine Neuropeptide Y receptor medicine.disease humanities Endocrinology Anesthesia Reperfusion Surgery Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Annals of Vascular Surgery. 8:350-355 |
| ISSN: | 0890-5096 |
| DOI: | 10.1007/bf02132996 |
| Popis: | Neuropeptide Y (NPY) is a potent vasoconstrictive polypeptide colocalized with norepinephrine in sympathetic neurons. The effects of ischemia and reperfusion on plasma NPY levels were studied and compared in the mongrel dog after infrarenal aortic cross-clamping. We found a two- to threefold increase in NPY levels during ischemia (initial 10.0 +/- 1.8 pmol/L vs. maximum 24.7 +/- 2.31 pmole/L, p < 0.001). The increase in NPY remained following reperfusion (initial 10.0 +/- 0.8 pmole/L vs. maximum 23.9 +/- 2.31 pmole/L, p < 0.001). These data reveal that NPY is released during ischemia and reperfusion and may be involved in mediating remote vascular events associated with infrarenal aortic cross-clamping. |
| Databáze: | OpenAIRE |
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