Diagnostic accuracy of technetium-99m-octreotide in imaging neuroendocrine tumors, Oman hospital experience with literature review

Autor:	Aymen Al Hadidi, Badriya Al Suqri, Naima Al Bulushi, Marwa Al Aamri, Mimouna Al Risi, Mohammed Al Zadjali, Hafidh Al Jahdami
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	lcsh:Medical physics. Medical radiology. Nuclear medicine medicine.medical_specialty lcsh:R895-920 Octreotide Neuroendocrine tumors somatostatin 030218 nuclear medicine & medical imaging Metastasis 03 medical and health sciences 0302 clinical medicine medicine Lung medicine.diagnostic_test business.industry Octreotide scan Gallium-68 Magnetic resonance imaging medicine.disease indium-111 medicine.anatomical_structure 030220 oncology & carcinogenesis Original Article Histopathology Radiology neuroendocrine tumors business technetium-99m Technetium-99m octreotide medicine.drug
Zdroj:	World Journal of Nuclear Medicine, Vol 18, Iss 2, Pp 137-142 (2019) World Journal of Nuclear Medicine
ISSN:	1450-1147
Popis:	The aim of this observational cross-sectional study with retrospective review of the data is to evaluate the efficacy of using technetium-99m-octreotide (Tc-99m-OCT) in imaging neuroendocrine tumors (NETs) in our tertiary care hospital. A total of 58 patients had Tc-99m-OCT were identified in our database, from January 2013 to December 2016. Forty-one patients (age range of 15–75 years) meet our inclusion criteria, namely histopathology proven NETs, Tc-99m-OCT scan, computed tomography (CT), or magnetic resonance imaging (MRI) done in our institute for correlation. Twenty-three patients had true positive Tc-99m-OCT scan. In addition to the primary tumors, the octreotide scan revealed metastasis in the lung, liver, and retroperitoneal lymph nodes. The smallest lesion detected on octreotide scan was a 4-mm pulmonary nodule that was missed on lung window CT scan. The Tc-99m-OCT had 17 true negative, one false negative, and no false positive. The CT and MRI scans had 18 true positive, 17 true negative, 5 false negative, and one false positive. The overall sensitivity, specificity, accuracy, positive, and negative predictive values of Tc-99m-OCT scan were 96%, 100%, 97%, 100%, and 94%, respectively. Whereas those of CT and MRI were 78%, 94%, 85%, 94%, and 77%, respectively. Our diagnostic accuracy of Tc-99m-OCT is high. We recommend that, in addition to the conventional radiological investigations, Tc-99m-OCT scan, or other somatostatin receptor imaging (SSR) is a mandate for better and accurate staging of patients with NETs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4a2e30ca9ef89fba2c42c2c1598696 http://www.wjnm.org/article.asp?issn=1450-1147 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.