Muscle contractile properties of cancer patients receiving chemotherapy: Assessment of feasibility and exercise effects

Autor: Laurien M. Buffart, Cornelis J de Ruijter, Mai J. M. Chinapaw, Teatske M. Altenburg, Inge R. H. M. Konings, Henk M.W. Verheul, Maike G. Sweegers, Cecile Grootscholten, Annette A. van Zweeden
Přispěvatelé: Epidemiology and Data Science, Medical oncology, CCA - Cancer Treatment and quality of life, Public and occupational health, Amsterdam Reproduction & Development (AR&D), APH - Methodology, APH - Health Behaviors & Chronic Diseases, Physiology, AMS - Sports
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
medicine.medical_specialty
Waiting Lists
Colorectal cancer
medicine.medical_treatment
Vascular damage Radboud Institute for Health Sciences [Radboudumc 16]
physical activity
Breast Neoplasms
Pilot Projects
Physical Therapy
Sports Therapy and Rehabilitation
Stimulation
law.invention
muscle contraction
Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14]
Randomized controlled trial
SDG 3 - Good Health and Well-being
law
Internal medicine
medicine
Humans
Orthopedics and Sports Medicine
Exercise
Netherlands
Chemotherapy
quadriceps muscle
business.industry
Quadriceps muscle
Cancer
Original Articles
Middle Aged
medicine.disease
Neoadjuvant Therapy
Chemotherapy
Adjuvant
Muscle fatigability
Colonic Neoplasms
Muscle Fatigue
randomized controlled trial
Linear Models
Cardiology
Feasibility Studies
Female
Original Article
fatigue
medicine.symptom
business
Muscle contraction
Zdroj: Scandinavian Journal of Medicine and Science in Sports, 30(10), 1918-1929. Blackwell Munksgaard
Buffart, L M, Sweegers, M G, de Ruiter, C J, Konings, I R, Verheul, H M W, van Zweeden, A A, Grootscholten, C, Chin A Paw, M J & Altenburg, T M 2020, ' Muscle contractile properties of cancer patients receiving chemotherapy: Assessment of feasibility and exercise effects ', Scandinavian Journal of Medicine and Science in Sports, vol. 30, no. 10, pp. 1918-1929 . https://doi.org/10.1111/sms.13758
Scandinavian Journal of Medicine & Science in Sports, 30, 10, pp. 1918-1929
Scandinavian Journal of Medicine & Science in Sports
Buffart, L M, Sweegers, M G, de Ruijter, C J, Konings, I R, Verheul, H M W, van Zweeden, A A, Grootscholten, C, Chinapaw, M J & Altenburg, T M 2020, ' Muscle contractile properties of cancer patients receiving chemotherapy : Assessment of feasibility and exercise effects ', Scandinavian Journal of Medicine and Science in Sports, vol. 30, no. 10, pp. 1918-1929 . https://doi.org/10.1111/sms.13758
Scandinavian Journal of Medicine & Science in Sports, 30, 1918-1929
ISSN: 1600-0838
0905-7188
DOI: 10.1111/sms.13758
Popis: Contains fulltext : 229899.pdf (Publisher’s version ) (Open Access) BACKGROUND: This pilot trial explores the feasibility of measuring muscle contractile properties in patients with cancer, effects of exercise during chemotherapy on muscle contractile properties and the association between changes in contractile muscle properties and perceived fatigue. METHOD: Patients who received (neo)adjuvant chemotherapy for breast or colon cancer were randomized to a 9-12 week exercise intervention or a waitlist-control group. At baseline and follow-up, we measured knee extensor strength using maximal voluntary contraction (MVC), contractile muscle properties of the quadriceps muscle using electrical stimulation, and perceived fatigue using the Multidimensional Fatigue Inventory. Feasibility was assessed by the proportion of patients who successfully completed measurements of contractile muscle properties. Exercise effects on muscle contractile properties were explored using linear regression analyses. Between-group differences >10% were considered potentially relevant. Pearson correlation (r(p) ) of changes in contractile muscle properties and changes in perceived fatigue was calculated. RESULTS: Twenty two of 30 patients completed baseline and follow-up assessments. Measurements of contractile properties were feasible except for muscle fatigability. We found a potentially relevant between-group difference in the rate of force development favoring the intervention group (1192 N/s, 95% CI = -335; 2739). Change in rate of force development was negatively correlated with change in perceived general (r(p) = -0.54, P = .04) and physical (r(p) = -0.59, P = .02) fatigue. CONCLUSION: Chemotherapy induces a decrease in the rate of force development, which may reflect a larger loss in type II muscle fibers. This may be attenuated with (resistance) exercise. The increase in the rate of force development was related to a decrease in perceived fatigue.
Databáze: OpenAIRE
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