Bacterial Cell–Cell Communication in the Host via RRNPP Peptide-Binding Regulators
| Autor: | David ePerez-Pascual, Veronique eMonnet, Rozenn eGardan |
|---|---|
| Přispěvatelé: | MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Institut National de la Recherche Agronomique (INRA) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Cell signaling commensalism Firmicutes Mini Review [SDV]Life Sciences [q-bio] 030106 microbiology lcsh:QR1-502 Peptide binding Context (language use) Biology Microbiology Bacterial cell structure lcsh:Microbiology commensalisme 03 medical and health sciences Microbiome firmicutes cell-cell communication quorum sensing biology.organism_classification Cell biology cell–cell communication virulence Quorum sensing firmicute Bacteria |
| Zdroj: | Frontiers in Microbiology Frontiers in Microbiology, Frontiers Media, 2016, 7, ⟨10.3389/fmicb.2016.00706⟩ Frontiers in Microbiology, Vol 7 (2016) Frontiers in Microbiology (7), . (2016) |
| ISSN: | 1664-302X |
| DOI: | 10.3389/fmicb.2016.00706 |
| Popis: | International audience; Human microbiomes are composed of complex and dense bacterial consortia. In these environments, bacteria are able to react quickly to change by coordinating their gene expression at the population level via small signaling molecules. In Gram-positive bacteria, cell-cell communication is mostly mediated by peptides that are released into the extracellular environment. Cell-cell communication based on these peptides is especially widespread in the group Firmicutes, in which they regulate a wide array of biological processes, including functions related to host-microbe interactions. Among the different agents of communication, the RRNPP family of cytoplasmic transcriptional regulators, together with their cognate re-internalized signaling peptides, represents a group of emerging importance. RRNPP members that have been studied so far are found mainly in species of bacilli, streptococci, and enterococci. These bacteria are characterized as both human commensal and pathogenic, and share different niches in the human body with other microorganisms. The goal of this mini-review is to present the current state of research on the biological relevance of RRNPP mechanisms in the context of the host, highlighting their specific roles in commensalism or virulence. |
| Databáze: | OpenAIRE |
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