Part IV: Basic Considerations of the Psoralens: Studies of Liver Function in Subjects Receiving Methoxsalen11From the Divisions of Metabolism and Dermatology, University of Oregon Medical School, Portland, Oregon

Autor:	J.Donald. Imbrie, Daniel H. Labby, Thomas B. Fitzpatrick
Rok vydání:	1959
Předmět:	Drug Pathology medicine.medical_specialty business.industry media_common.quotation_subject Methoxsalen Physiology Cell Biology Dermatology Biochemistry Hepatic function Clinical trial medicine Liver function business Molecular Biology media_common medicine.drug
Zdroj:	Journal of Investigative Dermatology. 32:273-275
ISSN:	0022-202X
DOI:	10.1038/jid.1959.46
Popis:	The chemical configuration of methoxsalen has been somewhat disturbing to investigators interested in hepatic function because of possible hepatotoxic activity. Some meager preliminary data suggesting that selective damage might occur was based on the finding of questionable elevation of occasional cephalin-cholesterol floc-culation tests. A systematic study of liver function with methoxsalen seemed indicated particularly in view of the projected widespread clinical trial which has since taken place over the last several months. Elliott in 1956, reporting on 22 patients receiving the drug, stated that two developed elevated bromsulphalein retention. Pretreatment examinations of liver function were not available so that the precise significance of these elevated tests is uncertain.
Databáze:	OpenAIRE
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