Immune-endocrine interactions related to a high risk of infections in chronic metabolic diseases: The role of PPAR gamma
| Autor: | Vinicius F. Carvalho, Ana Rosa Pérez, Adriana R. Silva, Cassiano Felippe Gonçalves-de-Albuquerque |
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| Rok vydání: | 2019 |
| Předmět: |
Risk
0301 basic medicine Peroxisome proliferator-activated receptor Endocrine System Inflammation Infections Sepsis 03 medical and health sciences 0302 clinical medicine Immune system Metabolic Diseases Diabetes mellitus medicine Animals Humans Pharmacology chemistry.chemical_classification Innate immune system business.industry medicine.disease PPAR gamma 030104 developmental biology chemistry Chronic Disease Immunology medicine.symptom Metabolic syndrome business 030217 neurology & neurosurgery Hormone |
| Zdroj: | European Journal of Pharmacology. 854:272-281 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2019.04.008 |
| Popis: | Diverse disturbances in immune-endocrine circuitries are involved in the development and aggravation of several chronic metabolic diseases (CMDs), including obesity, diabetes, and metabolic syndrome. The chronic inflammatory syndrome observed in CMDs culminates in dysregulated immune responses with low microbial killing efficiency, by means low host innate immune response, and loss of ability to eliminate the pathogens, which results in a high prevalence of infectious diseases, including pneumonia, tuberculosis, and sepsis. Herein, we review evidence pointing out PPARγ as a putative player in immune-endocrine disturbances related to increased risk of infections in CMDs. Cumulated evidence indicates that PPARγ activation modulates host cells to control inflammation during CMDs because of PPARγ agonists have anti-inflammatory and pro-resolutive properties, increasing host ability to eliminate pathogen, modulating hormone production, and restoring glucose and lipid homeostasis. As such, we propose PPARγ as a putative therapeutic adjuvant for patients with CMDs to favor a better infection control. |
| Databáze: | OpenAIRE |
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