Salivary duct carcinoma arising in IgG4-related autoimmune disease of the parotid gland
| Autor: | Mee Ling Yeong, Nick McIvor, Neville Angelo, Jespal Gill |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Pathology medicine.medical_specialty Sialadenitis Pathology and Forensic Medicine Salivary duct carcinoma Autoimmune Diseases stomatognathic system parasitic diseases Carcinoma Medicine Humans Parotid Gland Aged Autoimmune disease Sclerosis integumentary system Salivary gland business.industry fungi Chronic sclerosing sialadenitis medicine.disease Salivary Gland Neoplasms Submandibular gland Parotid gland medicine.anatomical_structure Immunoglobulin G Lymphatic Metastasis business |
| Zdroj: | Human pathology. 40(6) |
| ISSN: | 1532-8392 |
| Popis: | Hyper IgG4 disease or IgG4-related sclerosing/autoimmune disease is a multisystem condition characterized histologically by fibrosis, lymphoplasmacytic infiltration, and abundant IgG4 plasma cells associated with raised serum IgG4 levels. We present a case of salivary duct carcinoma of the parotid gland in a background of chronic sclerosing sialadenitis that also involved the submandibular gland with associated regional lymphadenopathy. The serology showed raised total IgG levels of 16.3 g/L (reference range, 6.0-15.0) and raised IgG4 levels of 3.41 g/L (reference range, 0.07-1.70). The salivary duct carcinoma contained areas of dense fibrosis and abundant IgG4-positive plasma cells (>100 per high-power field [hpf]). The adjacent noncarcinomatous areas, submandibular gland, and regional lymph nodes also contained plasma cells immunoreactive to IgG4 with densities higher than 100/hpf. To the best of our knowledge, this case is the first documentation of malignancy occurring in a background of IgG4-related autoimmune disease of the salivary gland. |
| Databáze: | OpenAIRE |
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