Intravesical Electrical Stimulation—An Experimental Analysis of The Mechanism of Action
| Autor: | Arno Ebner, Chonghe Jiang, Sivert Lindström |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Detrusor muscle
medicine.medical_specialty Lidocaine Urology Urinary Bladder Stimulation urologic and male genital diseases Contractility Internal medicine Reflex medicine Animals Urinary bladder business.industry Rats Inbred Strains Electric Stimulation female genital diseases and pregnancy complications Rats Mechanoreceptor Endocrinology medicine.anatomical_structure Mechanism of action Anesthesia Cats Female medicine.symptom business Muscle Contraction medicine.drug |
| Zdroj: | Journal of Urology. 148:920-924 |
| ISSN: | 1527-3792 0022-5347 |
| DOI: | 10.1016/s0022-5347(17)36778-2 |
| Popis: | The working mechanism of intravesical electrical stimulation (IVES) was evaluated in alpha-chloralose anaesthetized cats and rats. IVES involved a direct activation of bladder mechanoreceptor afferents of the A delta type and as a consequence a central reflex activation of the detrusor. The detrusor response was abolished by bilateral transection of the S1-S3 dorsal roots and by intravesical instillation of lidocaine. The optimal stimulation frequency was 20 Hz. The results offer a theoretical rationale for the use of IVES as treatment of weak detrusor contractility in man. |
| Databáze: | OpenAIRE |
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