Electron transfer properties of melanin
| Autor: | E.V. Gan, H F Haberman, I A Menon |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Melanins
integumentary system Chemistry Tyrosinase Biophysics Cytochrome c Group NAD Photochemistry Biochemistry Electron transport chain Redox Electron Transport Melanin Kinetics chemistry.chemical_compound Electron transfer Energy Transfer Product inhibition 2 6-Dichloroindophenol Ferricyanide Dichlorophenolindophenol Ferricyanides Oxidation-Reduction Molecular Biology NADP |
| Zdroj: | Archives of Biochemistry and Biophysics. 173:666-672 |
| ISSN: | 0003-9861 |
| Popis: | Melanin synthesized from mushroom tyrosinase and 3,4-dihydroxyphenylalanine has been shown to oxidize NADH and NADPH, reduce ferricyanide, oxidized forms of cytochrome c and dichlorophenolindophenol, and catalyze the coupled oxidation of NADH and reduction of ferricyanide. Kinetic studies involving the determination of initial velocity at various concentrations of substrates and product inhibition measurements have been carried out on the NADH-ferricyanide-melanin reaction. The results are consistent with a ping-pong mechanism in which one product is formed prior to the reaction of melanin with the second substrate involving the reversible oxidation and reduction of melanin during the reaction. It may be concluded that melanin is capable of acting as an electron transfer agent in several reduction-oxidation systems. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|