Retrospective comparison of pregnancy outcomes of fresh and frozen-warmed single blastocyst transfer: a 5-year single-center experience
| Autor: | Andrea Busnelli, Emanuela Morenghi, Leonora Grilli, Federico Cirillo, Paolo Emanuele Levi-Setti, Camilla Ronchetti, Ilaria Paladino |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Blastomeres medicine.medical_specialty Ovarian hyperstimulation syndrome Single Center Pregnancy Genetics Humans Medicine Blastocyst Assisted Reproduction Technologies Genetics (clinical) Retrospective Studies Cryopreservation business.industry Obstetrics Blastocyst Transfer Pregnancy Outcome Obstetrics and Gynecology Retrospective cohort study General Medicine Embryo Transfer medicine.disease Embryo transfer Placenta previa medicine.anatomical_structure Reproductive Medicine Female business Live birth Developmental Biology |
| Zdroj: | J Assist Reprod Genet |
| ISSN: | 1573-7330 1058-0468 |
| DOI: | 10.1007/s10815-021-02362-3 |
| Popis: | PURPOSE: To assess whether live birth rates (LBR) and maternal/neonatal complications differed following single fresh and frozen-warmed blastocyst transfer. METHODS: The present retrospective observational study analyzed 4,613 single embryo transfers (SET) (646 fresh and 3,967 frozen) from January 1, 2014, to December 31, 2018. Fresh embryo transfer at blastocyst stage was considered according to the age of the patient and her prognosis. In case of the risk of ovarian hyperstimulation syndrome, premature progesterone rise, non-optimal endometrial growth, or supernumerary embryos, cryopreservation with subsequent frozen embryo transfer (FET) was indicated. RESULTS: No differences in LBR were recorded. Fresh embryo transfers yielded an increase both in neonatal complications OR 2.15 (95% CI 1.20–3.86, p 0.010), with a higher prevalence of singletons weighting below the 5th percentile (p 0.013) and of intrauterine growth retardation (p 0.015), as well as maternal complications, with a higher placenta previa occurrence OR 3.58 (95% CI 1.54–8.28, p 0.003), compared to FET. CONCLUSION: LBR appears not to be affected by the transfer procedure preferred. Fresh embryo transfer is associated with higher risk of neonatal complications (specifically a higher prevalence of singletons weighting below the 5th percentile and of intrauterine growth retardation) and placenta previa. Reflecting on the increased practice of ART procedures, it is imperative to understand whether a transfer procedure yields less complications than the other and if it is time to switch to a “freeze-all” procedure as standard practice. Trial registration: Clinical Trial Registration Number: NCT04310761. Date of registration: March 17, 2020, retrospectively registered. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10815-021-02362-3. |
| Databáze: | OpenAIRE |
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