Alanine Aminotransferase and Gamma‐Glutamyl Transpeptidase Predict Histologic Improvement in Pediatric Nonalcoholic Steatohepatitis
| Autor: | Philip J. Rosenthal, Jean P. Molleston, Cynthia Behling, Tamir Miloh, Kimberly P. Newton, Mark Fishbein, Laura A. Wilson, Miriam B. Vos, Jeffrey B. Schwimmer, Ajay Jain, Joel E. Lavine, Karen F. Murray |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Nonalcoholic steatohepatitis medicine.medical_specialty Adolescent Cysteamine digestive system Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Non-alcoholic Fatty Liver Disease Predictive Value of Tests Fibrosis Internal medicine Nonalcoholic fatty liver disease medicine Humans Aspartate Aminotransferases Alanine aminotransferase Child Hepatology Receiver operating characteristic business.industry Remission Induction Alanine Transaminase Histology gamma-Glutamyltransferase Prognosis medicine.disease digestive system diseases Confidence interval Clinical trial Treatment Outcome 030104 developmental biology Liver Delayed-Action Preparations Female 030211 gastroenterology & hepatology business |
| Zdroj: | Hepatology |
| ISSN: | 1527-3350 0270-9139 |
| Popis: | BACKGROUND AND AIMS Predictive, noninvasive tools are needed to monitor key features of nonalcoholic fatty liver disease (NAFLD) in children that relate to improvement in liver histology. The purpose of this study was to evaluate the relationship between liver chemistries and liver histology using data from the CyNCh (Cysteamine Bitartrate Delayed-Release for the Treatment of NAFLD in Children) clinical trial. APPROACH AND RESULTS This study included 146 children. Improvement in liver histology, defined as decrease in nonalcoholic fatty liver disease (NAFLD) Activity Score ≥2 points without worsening of fibrosis, occurred in 43 participants (30%). There were 46 participants with borderline zone 1 nonalcoholic steatohepatitis (NASH) at baseline, with resolution in 28% (12 of 46). Multivariate models were constructed using baseline and change in alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT) at 52 weeks, for improvement in (1) liver histology primary outcome, (2) borderline zone 1 NASH, and (3) fibrosis. For improvement in histology, the model (P |
| Databáze: | OpenAIRE |
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