Effects of a high-calcium diet on serum insulin-like growth factor-1 levels in magnesium-deficient rats
Autor: | Yasutaka Kajita, Misao Miwa, Hiroshi Matsuzaki |
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Rok vydání: | 2012 |
Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry Serum insulin chemistry.chemical_element Biochemistry Internal medicine Male rats medicine Animals Magnesium Bone formation Insulin-Like Growth Factor I Rats Wistar Molecular Biology Calcium diet Calcium metabolism biology Chemistry Growth factor Diet Rats Endocrinology Osteocalcin biology.protein Calcium Magnesium Deficiency |
Zdroj: | Magnesium Research. 25:126-130 |
ISSN: | 1952-4021 0953-1424 |
Popis: | In order to clarify the effects of a high-calcium (Ca) diet on bone formation in magnesium (Mg)-deficient rats, this study focused on the effects of a high-Ca diet on serum insulin-like growth factor-1 (IGF-1) levels. Male rats were randomized by weight into four groups, and fed one of four experimental diets containing two different Mg concentrations (0.05% (normal-Mg) or Mg-free (Mg-deficient)), and two different Ca concentrations (0.5% (normal-Ca) or 1.0% (high-Ca)) for 14 days. Serum concentrations of osteocalcin and IGF-1 were significantly lower in rats fed the Mg-deficient diet than in rats fed the normal-Mg diet. On the other hand, dietary Ca concentration had no significant influence on serum concentrations of osteocalcin and IGF-1. This study suggested that: 1) a high-Ca diet has no preventive effects on the decreased bone formation seen in Mg-deficient rats; and 2) a high-Ca diet does not enhance serum IGF-1 levels in Mg-deficient rats. Moreover, unchanged serum IGF-1 concentrations may contribute to the decreased bone formation seen in Mg-deficient rats receiving a high-Ca diet. |
Databáze: | OpenAIRE |
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