Bivariate genome-wide association analysis strengthens the role of bitter receptor clusters on chromosomes 7 and 12 in human bitter taste

Autor:	Nicholas G. Martin, Paul A. S. Breslin, Margaret J. Wright, Scott D. Gordon, Gu Zhu, Liang-Dar Hwang, Danielle R. Reed, Puya Gharahkhani
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	0301 basic medicine Male Taste Genome-wide association study 030105 genetics & heredity Receptors G-Protein-Coupled chemistry.chemical_compound Genotype GWAS Receptor Child Genetics 0303 health sciences 030305 genetics & heredity Denatonium Taste Perception food and beverages Bitter Genetic Pleiotropy Taste Buds 3. Good health TAS2R38 Multigene Family Female Chromosomes Human Pair 7 psychological phenomena and processes Biotechnology Human Adult Adolescent lcsh:QH426-470 lcsh:Biotechnology Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide 03 medical and health sciences Young Adult stomatognathic system lcsh:TP248.13-248.65 SNP Humans Gene Chromosome 12 030304 developmental biology Chromosomes Human Pair 12 Models Genetic lcsh:Genetics 030104 developmental biology chemistry Perception Sucrose octaacetate Genome-Wide Association Study
Zdroj:	BMC Genomics, Vol 19, Iss 1, Pp 1-15 (2018)
ISSN:	1471-2164
DOI:	10.1186/s12864-018-5058-2
Popis:	Human perception of bitter substances is partially genetically determined. Previously we discovered a single nucleotide polymorphism (SNP) within the bitter taste receptor gene TAS2R19 on chromosome 12 that accounts for 5.8% of the variance in the perceived intensity rating of quinine, and we strengthened the classic association between TAS2R38 genotype and the bitterness of propylthiouracil (PROP). Here we performed a genome-wide association study (GWAS) using a 40% larger sample (n = 1999) together with a bivariate approach to detect previously unidentified common variants with small effects on bitter perception. We identified two signals, both with small effects (< 2%), within the bitter taste receptor clusters on chromosomes 7 and 12, which influence the perceived bitterness of denatonium benzoate and sucrose octaacetate respectively. We also provided the first independent replication for an association of caffeine bitterness on chromosome 12. Furthermore, we provided evidence for pleiotropic effects on quinine, caffeine, sucrose octaacetate and denatonium benzoate for the three SNPs on chromosome 12 and the functional importance of the SNPs for denatonium benzoate bitterness. These findings provide new insights into the genetic architecture of bitter taste and offer a useful starting point for determining the biological pathways linking perception of bitter substances.
Databáze:	OpenAIRE
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