Soluble corn fiber increases bone calcium retention in postmenopausal women in a dose-dependent manner: a randomized crossover trial
| Autor: | Courtney N. Henry, Steven A. Jakeman, Berdine R. Martin, Munro Peacock, George S. Jackson, Connie M. Weaver, George P. McCabe, Linda D McCabe |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Dietary Fiber medicine.medical_specialty Indiana Urinary system Medicine (miscellaneous) 030209 endocrinology & metabolism Zea mays Bone remodeling Cohort Studies 03 medical and health sciences 0302 clinical medicine Absorptiometry Photon N-terminal telopeptide Double-Blind Method Internal medicine medicine Humans Whole Body Imaging Fiber Osteoporosis Postmenopausal Aged Calcium metabolism 030109 nutrition & dietetics Nutrition and Dietetics Cross-Over Studies biology Bone Density Conservation Agents Chemistry Calcium Radioisotopes Middle Aged Crossover study Endocrinology Prebiotics Solubility Food Fortified Osteocalcin biology.protein Alkaline phosphatase Female Bone Remodeling Biomarkers |
| Zdroj: | The American journal of clinical nutrition. 104(3) |
| ISSN: | 1938-3207 |
| Popis: | BACKGROUND Dietary soluble corn fiber (SCF) significantly improves calcium absorption in adolescents and the bone strength and architecture in rodent models. OBJECTIVE In this study, we aimed to determine the skeletal benefits of SCF in postmenopausal women. DESIGN We used our novel technology of determining bone calcium retention by following the urinary appearance of (41)Ca, a rare long-lived radioisotope, from prelabeled bone to rapidly and sensitively evaluate the effectiveness of SCF in reducing bone loss. A randomized-order, crossover, double-blinded trial was performed in 14 healthy postmenopausal women to compare doses of 0, 10, and 20 g fiber from SCF/d for 50 d. RESULTS A dose-response effect was shown with 10 and 20 g fiber from SCF/d, whereby bone calcium retention was improved by 4.8% (P < 0.05) and 7% (P < 0.04), respectively. The bone turnover biomarkers N-terminal telopeptide and osteocalcin were not changed by the interventions; however, a significant increase in bone-specific alkaline phosphatase, which is a bone-formation marker, was detected between 0 and 20 g fiber from SCF/d (8%; P = 0.035). CONCLUSION Daily SCF consumption significantly increased bone calcium retention in postmenopausal women, which improved the bone calcium balance by an estimated 50 mg/d. This study was registered at clinicaltrials.gov as NCT02416947. |
| Databáze: | OpenAIRE |
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