15-Fluoro prostaglandin FP agonists: a new class of topical ocular hypotensives

Autor:	Mark R. Hellberg, Karen S. Haggard, Gary W. Williams, John B. Liao, Peter G. Klimko, Marsha A. McLaughlin, Bryon S. Severns, Najam A. Sharif
Rok vydání:	2004
Předmět:	Agonist medicine.medical_specialty Intraocular pressure genetic structures Side effect medicine.drug_class Administration Topical medicine.medical_treatment Receptors Prostaglandin Clinical Biochemistry Pharmaceutical Science Prostaglandin Ocular hypertension Ocular Hypotension medicine.disease_cause Biochemistry Fluorides chemistry.chemical_compound In vivo Internal medicine Drug Discovery medicine Animals Molecular Biology Molecular Structure Organic Chemistry Eye drop Haplorhini medicine.disease eye diseases Endocrinology chemistry Cats Prostaglandins Molecular Medicine Rabbits Irritation
Zdroj:	Bioorganic & Medicinal Chemistry. 12:3451-3469
ISSN:	0968-0896
DOI:	10.1016/j.bmc.2004.04.034
Popis:	A novel series of 15-fluoro prostaglandins with phenoxy termination of the omega-chain was synthesized and evaluated for binding and functional activation of the prostaglandin FP receptor in vitro and for side effect potential and topical ocular hypotensive efficacy in vivo. Compounds with the 15alpha-fluoride relative stereochemistry displayed EC50 values of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd3f4077fe51bf4946881e500b817cc4 https://doi.org/10.1016/j.bmc.2004.04.034 Zobrazit plný text záznamu Full Text from ScienceDirect