Sertraline Pharmacokinetics in HIV-Infected and Uninfected Children, Adolescents, and Young Adults
| Autor: | Suad Kapetanovic, Elizabeth Smith, Nathan John Hanan, Pim Brouwers, Benjamin Johnston, Brookie M. Best, Bobbie Graham, Edmund V. Capparelli, George K. Siberry, Mary E. Paul, Yanling Huo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Drug
medicine.medical_specialty Efavirenz pediatrics media_common.quotation_subject Disease 030204 cardiovascular system & hematology Pediatrics Paediatrics and Reproductive Medicine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pharmacokinetics Clinical Research 030225 pediatrics Internal medicine Psychiatric medication medicine Young adult antiretrovirals media_common Original Research Pediatric Sertraline Other Medical and Health Sciences business.industry sertraline lcsh:RJ1-570 Evaluation of treatments and therapeutic interventions virus diseases HIV lcsh:Pediatrics 3. Good health Infectious Diseases Good Health and Well Being chemistry 6.1 Pharmaceuticals Pediatrics Perinatology and Child Health Cohort HIV/AIDS Patient Safety business Infection pharmacokinetics medicine.drug |
| Zdroj: | Frontiers in Pediatrics Frontiers in Pediatrics, Vol 7 (2019) |
| ISSN: | 2296-2360 |
| Popis: | Objective: Due to potential disease and drug interactions, the appropriate sertraline starting dose and titration range may require adjustment in pediatric patients living with HIV. This is the first report of sertraline pharmacokinetics in HIV-infected youth. Methods: IMPAACT P1080 was a multicenter pilot study describing psychiatric medication pharmacokinetics in HIV-infected and uninfected youth. Participants were stable on sertraline, >6 to -0.5). Conclusions: HIV(-) cohort had the highest sertraline exposure. Sertraline exposure was ~40% lower in the PI/r cohort than in HIV(-); the need to alter sertraline dose ranges for PI/r participants is not clear. The impact of efavirenz on sertraline needs further investigation due to limited numbers of EFV participants. |
| Databáze: | OpenAIRE |
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