Tuberculosis Antigen-Specific T-Cell Responses During the First 6 Months of Antiretroviral Treatment
| Autor: | Robert J. Wilkinson, Katalin A. Wilkinson, Molebogeng X. Rangaka, Nishtha Jhilmeet, Catherine Riou |
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| Přispěvatelé: | Wellcome Trust |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pathogenesis and Host Response CD4-Positive T-Lymphocytes Male antiretroviral treatment HIV Infections Lymphocyte Activation 0302 clinical medicine Immunology and Allergy Sensitization 11 Medical and Health Sciences medicine.diagnostic_test biology immune reconstitution Flow Cytometry protection 3. Good health Infectious Diseases medicine.anatomical_structure tuberculosis Cohort Female Adult Tuberculosis Anti-HIV Agents T cell Microbiology immune activation Flow cytometry Mycobacterium tuberculosis 03 medical and health sciences Major Articles and Brief Reports Antigen Latent Tuberculosis medicine Antiretroviral treatment Humans Antigens Bacterial business.industry HLA-DR Antigens 06 Biological Sciences medicine.disease biology.organism_classification CD4 Lymphocyte Count 030104 developmental biology Immunology business Immunologic Memory Interferon-gamma Release Tests 030215 immunology |
| Zdroj: | The Journal of Infectious Diseases |
| Popis: | The reconstitution of Mycobacterium tuberculosis antigen-specific CD4 T cells in a cohort of HIV-infected persons starting antiretroviral treatment (ART) in a high tuberculosis endemic area is described. Restoration of the antigen-specific CD4 T-cell subsets mirrored the overall CD4 T-cell compartment. Activation (assessed by HLA-DR expression) decreased during ART but remained elevated compared to HIV-uninfected persons. Despite known M. tuberculosis sensitization determined by interferon-γ release assay, 12/23 participants had no M. tuberculosis-specific CD4 T cells detectable by flow cytometry, combined with overall elevated T-cell activation and memory differentiation, suggesting heightened turnover. Our data suggest early ART initiation to maintain polyfunctional immune memory responses. |
| Databáze: | OpenAIRE |
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