Isolated Anti-HBc: Significance and Management
| Autor: | Florian Moretto, Lionel Piroth, François-Xavier Catherine, Mathieu Blot, Clémentine Esteve |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
isolated anti-HBc antibodies medicine.medical_treatment Hbv reactivation HBV reactivation lcsh:Medicine viral hepatitis Review medicine.disease_cause Serology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine In patient 030203 arthritis & rheumatology Hepatitis B virus immunosuppression business.industry lcsh:R virus diseases Immunosuppression General Medicine medicine.disease hepatitis B infection Anti hbc Vaccination 030211 gastroenterology & hepatology business Viral hepatitis management |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 9, Iss 1, p 202 (2020) |
| ISSN: | 2077-0383 |
| Popis: | Hepatitis B virus (HBV) infection is prevalent worldwide and is associated with dramatic levels of morbidity and mortality. Isolated anti-HBc (IAHBc) is a particular serological pattern that is commonly found in immunocompromised patients. There is ongoing debate regarding the management of patients with IAHBc. Herein, we summarize the current guidelines and the newest evidence. The frequency of IAHBc is variable, with a higher prevalence in some populations, such as persons living with HIV and others immunocompromised patients. The risk of HBV reactivation depends on host factors (including immunosuppression) and viral factors. It is now well established that immunocompromised patients can be classified into three groups for risk according to the type of immunosuppression and/or treatment. In patients at high risk, HBV therapy has to be considered systematically. In patients at moderate risk, the decision is based on the level of HBV DNA (preemptive treatment or monitoring and vaccination). In patients with low risk, HBV vaccination is another possible approach, although further studies are needed to assess the type of preemptive strategy. |
| Databáze: | OpenAIRE |
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