Reduced vestibular perception thresholds in persistent postural-perceptual dizziness- a cross-sectional study

Autor:	Armin Scheffler, Mark Obermann, Steffen Naegel, Michael Nsaka, Christoph Kleinschnitz, Sebastian Wurthmann, Miriam Roesner, Dagny Holle
Rok vydání:	2021
Předmět:	medicine.medical_specialty Neurology genetic structures Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Neurologie Medizin Nystagmus Audiology Sitting Dizziness medicine otorhinolaryngologic diseases Humans motion sensitivity ddc:610 Motion perception RC346-429 functional vestibular disorder Medizinische Fakultät » Universitätsklinikum Essen » Center for Translational and Behavioral Neuroscience Vestibular system business.industry Somatosensory amplification Research General Medicine Cross-Sectional Studies Vestibular Diseases Reflex Vertigo Female Perception Persistent postural-perceptual dizziness Neurology. Diseases of the nervous system Neurology (clinical) sense organs medicine.symptom Vestibulo–ocular reflex business vestibular perceptual threshold
Zdroj:	BMC Neurology BMC Neurology, Vol 21, Iss 1, Pp 1-10 (2021)
ISSN:	1471-2377
Popis:	Background Persistent postural-perceptual dizziness (PPPD) is the most common functional vestibular disorder. A multisensory mismatch altered by psychological influences is considered to be an important pathophysiological mechanism. Increased cortical and subcortical excitability may play a role in the pathophysiology of PPPD. We hypothesized that decreased motion perception thresholds reflect one mechanism of the abnormal vestibular responsiveness in this disorder. We investigated the vestibular perception thresholds and the vestibular ocular reflex with a rotatory chair experiment to gain insights in the processing and adaption to vestibular provocation. Methods In this cross-sectional study 26 female PPPD patients and 33 healthy female age matched controls (HC) were investigated sitting in a motorized rotary chair shielded regarding visual and acoustic stimuli. The chair was rotated for 20 minutes with slowly increasing velocity to a maximum of 72°/s. We functionally tested motion perception thresholds and vegetative responses to rotation as well as vestibular-ocular reflex thresholds. We additionally investigated several psychological comorbidities (i.e. depression, anxiety, somatosensory amplification) using validated scores. Conventional dizziness scores were obtained to quantify the experienced dizziness and impact on daily life. Results PPPD patients showed a significant reduced vestibulo-perceptual threshold (PPPD: 10.9°/s vs. HC: 29.5°/s; pp=0.043). No significant difference was measured regarding nystagmus parameters between both groups. Conclusion PPPD patients showed increased vegetative response as well as decreased vestibulo-perceptual thresholds which are related to disease duration. This is of interest as PPPD might be sustained by increased vestibular excitability leading to motion intolerance and induction of dizziness when exposed to movement.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd3e2f10af267cd9fd6998f6e710a5b5 https://pubmed.ncbi.nlm.nih.gov/34641808 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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