Role of local contractile activity and muscle fiber type on LPL regulation during exercise
| Autor: | Brian S. Pavey, Marc T. Hamilton, Jacqueline Etienne, Alisha K. Holloway, Warren C. McClure |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Carboxylic Ester Hydrolases
medicine.medical_specialty Physiology Endocrinology Diabetes and Metabolism Muscle Fibers Skeletal Physical activity Physical exercise Biology Motor Activity Running Rats Sprague-Dawley chemistry.chemical_compound Immobilization Physiology (medical) Internal medicine Physical Conditioning Animal medicine Animals RNA Messenger Muscle fibre Muscle Skeletal Regulation of gene expression Lipoprotein lipase Triglyceride Heparin nutritional and metabolic diseases Skeletal muscle Electric Stimulation Hindlimb Rats Lipoprotein Lipase Endocrinology medicine.anatomical_structure chemistry lipids (amino acids peptides and proteins) Female Muscle Contraction |
| Zdroj: | The American journal of physiology. 275(6) |
| ISSN: | 0002-9513 |
| Popis: | The purpose of this study was to determine the influence of local contractile activity on lipoprotein lipase (LPL) regulation in skeletal muscle. Short-term voluntary run training increased LPL mRNA concentration and LPL immunoreactive mass about threefold in white skeletal muscles of the rat hindlimb (all P < 0.01). Training also increased total and heparin-releasable LPL enzyme activity in white hindlimb muscles and in postheparin plasma ( P< 0.05). Training did not enhance LPL regulation in a white muscle that was not recruited during running (masseter). LPL levels were already high in red skeletal muscles of control rats, and training did not result in a further rise. In resting rats, local electrical stimulation of a motor nerve to a predominantly white muscle caused a significant rise in LPL mRNA, immunoreactive mass, and enzyme activity relative to the contralateral control muscle of the same animals (all P < 0.01). Finally, LPL expression was several times greater in a red muscle (soleus) of rats with normal postural activity than rats with immobilized hindlimbs ( P < 0.01). In summary, these studies support the hypothesis that local contractile activity is required for increasing LPL expression during exercise training and for maintaining a high level of LPL expression in postural muscles. |
| Databáze: | OpenAIRE |
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