Idiopathic hyperammonemia after chemotherapy with vinorelbine, topotecan, and cisplatin in a patient with acute lymphocytic leukemia
| Autor: | Chunyu Liu, Tzeon Jye Chiou, Yu Hsien Chen, Yen Ning Hsu |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Oncology
Vincristine medicine.medical_specialty Cyclophosphamide medicine.medical_treatment Antineoplastic Agents ThioTEPA Vinorelbine Vinblastine lcsh:RC254-282 Young Adult Internal medicine Acute lymphocytic leukemia medicine Humans Hyperammonemia Chemotherapy business.industry lcsh:RC633-647.5 Combination chemotherapy General Medicine lcsh:Diseases of the blood and blood-forming organs Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Liver Topotecan Drug Therapy Combination Female Cisplatin business medicine.drug |
| Zdroj: | Hematology/Oncology and Stem Cell Therapy, Vol 3, Iss 4, Pp 199-202 (2010) |
| ISSN: | 1658-3876 |
| DOI: | 10.5144/1658-3876.2010.199 |
| Popis: | Idiopathic hyperammonemia (IHA) had been reported in some patients with hematological malignancy after receiving intensive chemotherapy, following bone marrow transplantation, or after using 5-fluoro-uracil for some solid tumors. The chemotherapeutic agents involved include cytarabine, daunomycin, cyclophosphamide, vincristine, amsacrine, etoposide, asparaginase, busulfan, and methotraxate, all used for treating hematological malignancies. No previous reports have described the association between idiopathic hyperammonemia and combined chemotherapy with vinorelbine, topotecan, and cisplatin. We describe a 20-year-old girl with normal liver function and relapsed precursor B-lymphoblastic leukemia receiving the modified TVTG (topotecan, vinorelbine, thiotepa, dexamethasone, and gemcitabine) protocol to control her disease. We used cisplatin (30 mg/m2/day) to replace thiotepa on day 3 because thiotepa was not available in Taiwan. The patient developed acute idiopathic hyperammonemia after 5 days of chemotherapy and died 9 days after chemotherapy. To our knowledge, this patient is the first report of the association of hyperammonemia and chemotherapy with vinorelbine, topotecan, and cisplatin in the English literature. |
| Databáze: | OpenAIRE |
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