Microglia as Dynamic Cellular Mediators of Brain Function
| Autor: | Elizabeth C. Wright-Jin, David H. Gutmann |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Central Nervous System
0301 basic medicine Nervous system Aging Central nervous system Synaptogenesis Context (language use) Disease Biology Article 03 medical and health sciences 0302 clinical medicine medicine Animals Homeostasis Humans Autistic Disorder Molecular Biology Progenitor Neurons Microglia Brain Neoplasms Brain Cell Differentiation Neurodegenerative Diseases 030104 developmental biology medicine.anatomical_structure Cellular Microenvironment Astrocytes Synapses Molecular Medicine Inflammation Mediators Neuroscience Biomarkers 030217 neurology & neurosurgery Astrocyte |
| Zdroj: | Trends Mol Med |
| ISSN: | 1471-4914 |
| DOI: | 10.1016/j.molmed.2019.08.013 |
| Popis: | Originally hypothesized to function solely as immunologic responders within the central nervous system (CNS), emerging evidence has revealed that microglia have more complex roles in normal brain development and in the context of disease. In health, microglia influence neural progenitor fate decisions, astrocyte activation, neuronal homeostasis, and synaptogenesis. In the setting of brain disease, including autism, brain tumors, and neurodegenerative disorders, microglia undergo substantial morphological, molecular, and functional changes, which establish new biological states relevant to disease pathogenesis and progression. In this review, we discuss the function of microglia in health and disease, and outline a conceptual framework for elucidating their specific contributions to nervous system pathobiology. |
| Databáze: | OpenAIRE |
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