Germacrone: A Potent Secondary Metabolite with Therapeutic Potential in Metabolic Diseases, Cancer and Viral Infections
| Autor: | Fariha Rukhsar, Nazia Kanwal, Ammara Riaz, Iqra Sarfraz, Muhammad Ajmal Shah, Rubab Ishfaq, Rabia Batool, Şevki Adem, Azhar Rasul, Ghulam Hussain |
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| Rok vydání: | 2020 |
| Předmět: |
Cell signaling
Cell cycle checkpoint medicine.drug_class Clinical Biochemistry Secondary Metabolism Germacrone Antineoplastic Agents Pharmacology Secondary metabolite 030226 pharmacology & pharmacy Neuroprotection Anti-inflammatory 03 medical and health sciences chemistry.chemical_compound Magnoliopsida Sesquiterpenes Germacrane 0302 clinical medicine Anti-Infective Agents Metabolic Diseases Neoplasms Medicine Animals Humans business.industry Cancer Drug Synergism medicine.disease chemistry Apoptosis Virus Diseases 030220 oncology & carcinogenesis business medicine.drug |
| Zdroj: | Current drug metabolism. 21(14) |
| ISSN: | 1875-5453 |
| Popis: | Natural products, an infinite reserve of bioactive molecules, will continue to serve humans as an important source of therapeutic agents. Germacrone is a bioactive natural compound found in the traditional medicinal plants of family Zingiberaceae. This multifaceted chemical entity has become a point of focus during recent years due to its numerous pharmacological applications, e.g., anticancer, anti-inflammatory, antiviral, antioxidant, anti-adipogenic, anti-androgenic, antimicrobial, insecticidal, and neuroprotective. Germacrone is an effective inducer of cell cycle arrest and apoptosis in various cancers (breast, brain, liver, skin, prostate, gastric, and esophageal) via modulation of different cell signaling molecules and pathways involved in cancer proliferation. This is the first report highlighting the wide spectrum of pharmacological activities exhibited by germacrone. The reported data collected from various shreds of evidences recommend that this multifaceted compound could serve as a potential drug candidate in the near future. |
| Databáze: | OpenAIRE |
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