| Popis: |
Cyclohexanol and its derivatives 2-(o-tolyl), 2-(m-tolyl), 2-(p-tolyl), 2-(o-chlorophenyl), 2-(m-chlorophenyl), and 2-(p-chlorophenyl) were tested for cardioplegic effects on intact anesthetized rats, isolated guinea pig hearts, and isolated rabbit atria. Most of the compounds produced inhibitory effects varying from a slight depression to complete arrest. Evaluation of potency was based on the ability to produce arrest and the duration of arrest. In both series of substitutions it appears that the trans-2-o-derivatives are most potent with the cis-2-o-derivatives least potent. The 2-m-and 2-(p-chlorophenyl) compounds appear to be toxic to the myocardium as the hearts do not return to their normal level of activity. Mechanism studies indicate an antagonistic effect between these compounds and calcium. |
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