Associations between body size and serum estradiol and sex hormone-binding globulin levels in premenopausal African American women
| Autor: | Lovell A. Jones, Raheem J. Paxton, Beverly J. Gor, Mike Hernandez, Denae W. King, Celia Garcia-Prieto, Shahnjayla K. Connors |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty Waist Endocrinology Diabetes and Metabolism Clinical Biochemistry Context (language use) Breast Neoplasms Overweight Biochemistry Endocrinology Sex hormone-binding globulin Breast cancer Waist–hip ratio Risk Factors Internal medicine Sex Hormone-Binding Globulin Follicular phase Medicine Body Fat Distribution Body Size Humans Obesity biology Estradiol business.industry Waist-Hip Ratio Biochemistry (medical) JCEM Online: Brief Reports Middle Aged medicine.disease Black or African American Follicular Phase Premenopause biology.protein Linear Models Female medicine.symptom business |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 98(3) |
| ISSN: | 1945-7197 |
| Popis: | African American (AA) women have the highest rates of premenopausal breast cancer; however, it is unclear whether body size contributes to the hormonal patterns potentially associated with increased breast cancer risk in these women.To characterize the association between body size and serum levels of estradiol and sex hormone-binding globulin (SHBG) levels in a sample of premenopausal AA women.A total of 164 premenopausal AA women who were not pregnant or breastfeeding were recruited for this study. Serum samples were collected during the early follicular phase, and trained staff collected body size measurements. Multiple linear regression models were performed to assess potential associations.Serum estradiol and SHBG levels.Many (81%) of the women enrolled were overweight or obese. Both waist-to-hip ratio (WHR) (β = 2.68, P = .008) and waist circumference (WC) (β = 2.02, P = .046) were positively associated with higher levels of estradiol. All measures of body was significantly and inversely associated with SHBG levels (all P.05).Premenopausal AA women with higher WHR or larger WC may have higher levels of estradiol and lower levels of SHBG. Thus, WHR or WC may be better indicators for assessing hormonal patterns implicated in breast cancer pathogenesis in these women. |
| Databáze: | OpenAIRE |
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