Bronchial allergen challenge in subjects with low levels of allergic sensitization to indoor allergens
| Autor: | AM Witteman, HM Jansen, JS Van Der Zee, M Mulder, RC Aalberse |
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| Přispěvatelé: | Other departments |
| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Allergy Immunology Provocation test medicine.disease_cause Bronchial Provocation Tests Allergic sensitization Allergen Radioallergosorbent Test medicine Hypersensitivity Immunology and Allergy Animals Humans Antigens Dermatophagoides Sensitization Glycoproteins Rhinitis Skin Tests Mites medicine.diagnostic_test business.industry Radioallergosorbent test Aeroallergen Immunoglobulin E Middle Aged respiratory system medicine.disease Asthma Respiratory Function Tests respiratory tract diseases medicine.anatomical_structure Bronchial hyperresponsiveness Cats Female business Histamine |
| Zdroj: | Allergy, 54(4), 366-374. Wiley-Blackwell |
| ISSN: | 0105-4538 |
| Popis: | Background: Low skin reactivity to common inhalant allergens is frequently found in asymptomatic individuals as well as in patients with respiratory complaints. However, most studies on bronchial allergen challenge concern patients with high levels of allergic sensitization. The present study was directed to bronchial reactions after allergen challenge in subjects with low skin reactivity to Dermatophagoides pteronyssinus or cat dander. Methods: Titrated intracutaneous skin tests, skin prick tests, specific IgE assays, histamine release on washed leukocytes, and bronchial histamine and allergen-challenge tests were performed in 20 subjects with an intracutaneous skin test threshold for cat dander (Felis domesticus) or D. pteronyssinus above 0.1 BU/ml (mean wheal diameter in skin prick test with 10 000 BU/ml: 4.4 mm). Ten of the 20 patients had specific IgE below the detection limit in at least one of the three IgE assays which were done. Fifteen patients had a specific IgE level below 2 kU/l in all three tests. As a positive control group, the same parameters were studied in seven moderately sensitized patients with an intracutaneous skin test threshold below 0.1 BU/ml (mean wheal diameter with 10 000 BU/ml: 7.2 mm). Results: The 20 subjects with low levels of allergic sensitization had an early decrease in FEV1 of 8.6% (P |
| Databáze: | OpenAIRE |
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