Voluntary Wheel Running Selectively Augments Insulin-Stimulated Vasodilation in Arterioles from White Skeletal Muscle of Insulin-Resistant Rats
| Autor: | Catherine R. Mikus, M. H. Laughlin, John P. Thyfault, Sarah J. Borengasser, Grace M. Uptergrove, Angelina M. Taylor, Jessica L. Libla, R. Rector, Jamal A. Ibdah, E. Matthew Morris, Douglas J. Oberlin, Bruno T. Roseguini |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Physiology Rats Inbred OLETF medicine.medical_treatment Vasodilation Carbohydrate metabolism Article Insulin resistance Physical Conditioning Animal Physiology (medical) Internal medicine medicine Animals Insulin Muscle Skeletal Molecular Biology computer.programming_language biology sed business.industry Skeletal muscle medicine.disease Endothelin 1 Rats Arterioles Insulin receptor Glucose Endocrinology medicine.anatomical_structure biology.protein Insulin Resistance Cardiology and Cardiovascular Medicine business computer Signal Transduction |
| Zdroj: | Microcirculation. 19:729-738 |
| ISSN: | 1073-9688 |
| DOI: | 10.1111/j.1549-8719.2012.00210.x |
| Popis: | Background Exercise (RUN) prevents declines in insulin-mediated vasodilation, an important component of insulin-mediated glucose disposal, in rats prone to obesity and insulin resistance. Objective Determine whether RUN (1) improves insulin-stimulated vasodilation after insulin resistance has been established, and (2) differentially affects arterioles from red and white muscle. Methods Insulin signaling and vasoreactivity to insulin (1–1000 μIU/mL) were assessed in 2A from the Gw and Gr of SED OLETF rats at 12 and 20 weeks of age (SED12, SED20) and those undergoing RUN (RUN20) or caloric restriction (CR20; to match body weight of RUN) from 12 to 20 weeks. Results Glucose and insulin responses to i.p. glucose were reduced in RUN20, elevated in SED20 (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|