A Stereolithography-Based 3D Printed Hybrid Scaffold for In Situ Cartilage Defect Repair
Autor: | Andrew A. Tomaschke, Cecilia Pascual-Garrido, Robert R. McLeod, Archish Muralidharan, Stephanie J. Bryant, Virginia L. Ferguson, Eric Kleinjan, Elizabeth A. Aisenbrey |
---|---|
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
In situ Cartilage Articular Scaffold 3d printed Defect repair Materials science Stereolithography Polymers and Plastics Light Chondral defect Bioengineering 02 engineering and technology Article law.invention Polyethylene Glycols Polymerization Biomaterials 03 medical and health sciences law Materials Chemistry medicine Animals Wound Healing Tissue Scaffolds Cartilage 021001 nanoscience & nanotechnology 030104 developmental biology medicine.anatomical_structure Cartilage cells Printing Three-Dimensional Cattle 0210 nano-technology Biotechnology Biomedical engineering |
Zdroj: | Macromolecular bioscience. 18(2) |
ISSN: | 1616-5195 |
Popis: | Damage to articular cartilage can over time cause degeneration to the tissue surrounding the injury. To address this problem, scaffolds that prevent degeneration and promote neotissue growth are needed. We introduce a new hybrid scaffold that combines a stereolithography-based three-dimensional printed support structure with an injectable and photopolymerizable hydrogel for delivering cells to treat focal chondral defects. In this proof of concept study, we demonstrate the ability to a) infill the support structure with an injectable hydrogel precursor solution, b) incorporate cartilage cells during infilling using a degradable hydrogel that promotes neotissue deposition, and c) minimize damage to the surrounding cartilage when the hybrid scaffold is placed in situ in a focal chondral defect in an osteochondral plug that is cultured under mechanical loading. With the ability to independently control the properties of the structure and the injectable hydrogel, this hybrid scaffold approach holds promise for treating chondral defects. |
Databáze: | OpenAIRE |
Externí odkaz: |