Improved rejection of multiply scattered photons in confocal microscopy using dual-axes architecture
| Autor: | Michael J. Mandella, Thomas D. Wang, Gordon S. Kino, Larry K. Wong |
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| Rok vydání: | 2007 |
| Předmět: |
Point spread function
Optics and Photonics Photon Chemical Phenomena Confocal Quantitative Biology::Tissues and Organs Monte Carlo method Article law.invention Quantitative Biology::Cell Behavior Optics Confocal microscopy law Microscopy Scattering Radiation Ballistic photon Physics Photons Microscopy Confocal Models Statistical business.industry Chemistry Physical Equipment Design Models Theoretical Atomic and Molecular Physics and Optics Photon counting Anisotropy business Monte Carlo Method |
| Zdroj: | Optics letters. 32(12) |
| ISSN: | 0146-9592 |
| Popis: | We perform Monte Carlo simulations to show that the dual-axes (DA) confocal architecture has superior rejection of multiply scattered photons in tissue to that of single axis. As a result, the DA configuration provides improved signal-to-noise ratio and dynamic range, and thus is sensitive to ballistic photons from deeper within tissue, features that are particularly useful for performing vertical cross-sectional reflectance images in tissue. |
| Databáze: | OpenAIRE |
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