Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation
| Autor: | Teresa T. Bonello, Mark Peifer |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Scaffold protein
Cell division Protein family Polarity (physics) Synaptogenesis Reviews Context (language use) Review Biology 03 medical and health sciences 0302 clinical medicine Cell polarity Cell Adhesion Animals Drosophila Proteins Cell Proliferation 030304 developmental biology 0303 health sciences Cell Polarity Membrane Proteins Cell Biology biology.organism_classification Cell biology Drosophila melanogaster Multiprotein Complexes 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | The Journal of Cell Biology |
| ISSN: | 1540-8140 0021-9525 |
| DOI: | 10.1083/jcb.201810103 |
| Popis: | Bonello and Peifer summarize recent advances in our understanding of how the scaffolding protein Scribble regulates polarity, adhesion, proliferation, and neuronal function. Key events ranging from cell polarity to proliferation regulation to neuronal signaling rely on the assembly of multiprotein adhesion or signaling complexes at particular subcellular sites. Multidomain scaffolding proteins nucleate assembly and direct localization of these complexes, and the protein Scribble and its relatives in the LAP protein family provide a paradigm for this. Scribble was originally identified because of its role in apical–basal polarity and epithelial integrity in Drosophila melanogaster. It is now clear that Scribble acts to assemble and position diverse multiprotein complexes in processes ranging from planar polarity to adhesion to oriented cell division to synaptogenesis. Here, we explore what we have learned about the mechanisms of action of Scribble in the context of its multiple known interacting partners and discuss how this knowledge opens new questions about the full range of Scribble protein partners and their structural and signaling roles. |
| Databáze: | OpenAIRE |
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