Ethical Issues in the Use of Genetic Markers in Occupational Epidemiologic Research
| Autor: | Paul A. Schulte, Michael J. Colligan, Elizabeth Ward, Geoffrey P. Lomax |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Genetic Markers
Genetic Research medicine.medical_specialty Public information Informed Consent Ethical issues business.industry Medical screening Public Health Environmental and Occupational Health Risk Assessment Ethics Research Occupational Diseases Occupational medicine Epidemiologic Studies Genetic marker Occupational Exposure Humans Medicine Ethics Medical Genetic Predisposition to Disease Engineering ethics Occupational exposure Epidemiologic research Genetic Privacy business |
| Zdroj: | Journal of Occupational and Environmental Medicine. 41:639-646 |
| ISSN: | 1076-2752 |
| Popis: | This review was conducted to characterize the nature of contemporary occupational epidemiologic research involving genetic markers, consider how genetic information is unique with regard to its social applications, and examine some of the ethical dilemmas that may arise over the course of studies. We have reviewed the literature and the lessons from our experience in conducting occupational epidemiologic research involving genetic markers. This review describes how occupational epidemiologic studies differ from other epidemiologic studies on issues of participation, confidentiality, and the history of including genetic markers. Of primary concern in occupational studies are genes that have multiple alleles and are sometimes referred to as "metabolic polymorphisms." They generally do not confer risk on their own but rather only in combination with a specific exposure. There is a need for a clear policy and guidelines for the conduct of occupational epidemiologic studies using genetic material. This policy should address all of the steps in study design, implementation, interpretation, and communication of results. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|