Possible effect of epinephrine in minimizing COVID-19 severity: a review

Autor: Mory Ghomshei, Hamid R. Ansarian, Mahnaz Derakhshan
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Medicine (General)
Disease
CD8-Positive T-Lymphocytes
Severity of Illness Index
Biochemistry
law.invention
0302 clinical medicine
law
030212 general & internal medicine
Child
Age Factors
General Medicine
Prognosis
Intensive care unit
Special Issue: Coronavirus Outbreak: A Serious Public Health Issue
Epinephrine
medicine.symptom
Coronavirus Infections
medicine.drug
Adult
circadian rhythm
medicine.medical_specialty
2019-20 coronavirus outbreak
Coronavirus disease 2019 (COVID-19)
Pneumonia
Viral
macromolecular substances
CD8+ T cells
Asymptomatic
Drug Administration Schedule
03 medical and health sciences
R5-920
Severity of illness
medicine
Humans
epinephrine
Pandemics
Asymptomatic Diseases
adrenaline
business.industry
Biochemistry (medical)
Models
Immunological
COVID-19
Cell Biology
Immunity
Innate
epinephrine pulse
030104 developmental biology
Emergency medicine
business
Biomarkers
Zdroj: The Journal of International Medical Research
Journal of International Medical Research, Vol 48 (2020)
ISSN: 1473-2300
0300-0605
Popis: Objective Coronavirus disease 2019 (COVID-19) shows a wide range of severity, ranging from an asymptomatic presentation to a severe illness requiring intensive care unit admission. Identification of a strategy to manage the severity of this disease will not only help to reduce its case fatality but also help to remove some of the burden from the already overwhelmed health care systems. While successful management of symptoms in general is important, identifying measures to modify the severity of the illness is a key factor in the fight against this pandemic. Methods This paper presents a short literature review to suggest a new treatment modality for COVID-19. Results COVID-19 is less severe and rarely fatal in children than in adults, which could be caused by greater fluctuations of plasma epinephrine in children. Our literature survey endorses this hypothesis according to both the epidemiological and immunological findings. Conclusion Application of epinephrine pulses with a specific amplitude may be considered an intervention to minimize the severity of COVID-19.
Databáze: OpenAIRE
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