A testing device for evaluation of gas transfer through synthetic membranes
| Autor: | Andre Sausse, André Lautier, Alain Granger, Daniel N. Laurent |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Extracorporeal Circulation
Chromatography Capillary action Extracorporeal circulation Silicones Biomedical Engineering Synthetic membrane Membranes Artificial Carbon Dioxide Chemistry Techniques Analytical Permeability Volumetric flow rate Oxygen Biomaterials chemistry.chemical_compound Silicone Membrane chemistry Blood oxygenator Methods Humans Semipermeable membrane Cellulose |
| Zdroj: | Journal of Biomedical Materials Research. 4:189-221 |
| ISSN: | 1097-4636 0021-9304 |
| Popis: | An experimental set-up was designed to allow the determination of the gas transfer rates between human blood and pure O2 through a synthetic membrane. This device permitted the obtention of known steady states. It consisted of a thermostated closed blood loop containing a capillary oxygenating cell with a functional area of 400 cm2. The thickness of the blood film in the capillaries was about 150 μ. The type of membrane under study consisted of a supporting cellulosic paper, impregnated with a silicone elastomer. The manufacturing process allowed to get reproduceable hydrophobic microporous membranes without selective permeability in gas to gas phase. The continuous evaluation of the “expired” CO2 flow rate was achieved with an accurate titration method. O2 and CO2 transfer rates were also determined on the blood phase. In parallel mounting of two oxygenators permitted an intercomparison of membranes. The results gained from this study permitted to consider one of these membranes (6.5 g silicone/m2) as suitable for incorporation into a blood oxygenator. Moreover, agitation of the blood capillaries at a suitable frequency resulted in a substantial increase of O2 and CO2 transfer rates. |
| Databáze: | OpenAIRE |
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