Biomarkers of endothelial dysfunction: can they help us deciphering systemic inflammation and sepsis?
| Autor: | Patrick Paulus, Carla Jennewein, Kai Zacharowski |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Vascular Endothelial Growth Factor A
Endothelium Multiple Organ Failure Health Toxicology and Mutagenesis Clinical Biochemistry Ischemia ADAMTS13 Protein Inflammation Systemic inflammation Biochemistry Angiopoietin-2 Fibrin Fibrinogen Degradation Products Sepsis Intensive care Plasminogen Activator Inhibitor 1 von Willebrand Factor Angiopoietin-1 medicine Humans Endothelial dysfunction Child Platelet-Derived Growth Factor Endothelin-1 Septic shock business.industry Infant Newborn medicine.disease Shock Septic Urokinase-Type Plasminogen Activator Neoplasm Proteins ADAM Proteins medicine.anatomical_structure Immunology Selectins Proteoglycans Endothelium Vascular medicine.symptom business Biomarkers |
| Zdroj: | Biomarkers. 16:S11-S21 |
| ISSN: | 1366-5804 1354-750X |
| Popis: | The endothelial integrity, as mechanical barrier against microorganisms and as natural "anticoagulant", is crucial for physiologic organ function. Systemic activation of the endothelium upon inflammation, sepsis, and septic shock is always ending in blood-tissue barrier disruption. With increasing dysfunction, uncontrolled clotting activation, capillary microthrombi formation, tissue edema, local hypoxia, and ischemia are initiated. This in turn enhances a vicious circle leading to multiple organ failure and death. Therefore, biomarkers reflecting this special compartment may help in the early detection of systemic inflammation and its complications. This review provides an overview of the most important endothelial biomarkers and their possible use in sepsis. |
| Databáze: | OpenAIRE |
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