Somatic gonad sheath cells and Eph receptor signaling promote germ-cell death in C. elegans
| Autor: | X Li, Ian D. Chin-Sang, R W Johnson, Helen M. Chamberlin, D Park |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Programmed cell death
Cell Apoptosis Cell Cycle Proteins Biology Cell fate determination Germline medicine Animals Caenorhabditis elegans Caenorhabditis elegans Proteins Gonads Molecular Biology Mitogen-Activated Protein Kinase Kinases Original Paper Erythropoietin-producing hepatocellular (Eph) receptor Receptor Protein-Tyrosine Kinases Cell Biology biology.organism_classification Cell biology Germ Cells medicine.anatomical_structure Mutation RNA Interference Germ cell Signal Transduction |
| Zdroj: | Cell Death & Differentiation. 19:1080-1089 |
| ISSN: | 1476-5403 1350-9047 |
| Popis: | Programmed cell death eliminates unwanted cells during normal development and physiological homeostasis. While cell interactions can influence apoptosis as they do other types of cell fate, outside of the adaptive immune system little is known about the intercellular cues that actively promote cell death in healthy cells. We used the Caenorhabditis elegans germline as a model to investigate the extrinsic regulators of physiological apoptosis. Using genetic and cell biological methods, we show that somatic gonad sheath cells, which also act as phagocytes of dying germ cells, promote death in the C. elegans germline through VAB-1/Eph receptor signaling. We report that the germline apoptosis function of VAB-1 impacts specific cell death pathways, and may act in parallel to extracellular signal-regulated kinase MAPK signaling. This work defines a non-autonomous, pro-apoptotic signaling for efficient physiological cell death, and highlights the dynamic nature of intercellular communication between dying cells and the phagocytes that remove them. |
| Databáze: | OpenAIRE |
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