Is shortage of heart donors a real problem? Insights from a Brazilian Mid-West heart transplant program
| Autor: | Rodrigo Biondi, Claudio Ribeiro da Cunha, Pedro H M Peres, Vitor Salvatore Barzilai, Marcelo Botelho Ulhoa, Camila Scatolin Moraes, Renato B. Chaves, Fernando Antibas Atik, Felipe Bezzera Martins de Oliveira |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty medicine.medical_treatment Primary Graft Dysfunction 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Organ donation Heart transplantation Proportional hazards model business.industry Hazard ratio medicine.disease Confidence interval Tissue Donors Log-rank test 030228 respiratory system Heart failure Heart Transplantation Surgery Cardiology and Cardiovascular Medicine business Brazil |
| DOI: | 10.22541/au.158880217.70645898 |
| Popis: | BACKGROUND AND AIM OF THE STUDY In developed countries, the shortage of viable donors is the main limiting factor of heart transplantation. The aim of this study is to determine whether the same reality applies to Brazil. METHODS Between January 2012 and December 2014, 299 adult heart donor offers were studied in terms of donor profiles and reasons for refusal. The European donor scoring system was calculated, being high-risk donors defined as more than 17 points. The donor scoring system was used to objectively determine the donor profile and correlate with donor acceptance and posttransplant primary graft dysfunction and recipient survival. Cox proportional hazard model was used in determining the predictors of long-term mortality. RESULTS The rates of donor acceptance and heart transplants performed were 45.8% and 19.3%, respectively. Reasons for refusal were mostly nonmedical (53.7%). The majority of donors were classified as high-risk (65.5%). Hearts from high-risk donors did not impact primary graft dysfunction (14.3% vs 10%; P = .6), neither long-term survival (P = .4 by logrank test). Recipient's age was greater than 50 years (hazard ratio, 6.02; 95% confidence interval, 2.41-16.08; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|