Involvement of NLRP3 inflammasome in schizophrenia-like behaviour in young animals after maternal immune activation
| Autor: | Bruna Becker da Silva, Matheus L Dutra, Aline D Schlindwein, Letícia Ventura, Paula Dias, Viviane Freiberger, Clarissa M. Comim, Vinicius B Thiesen |
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| Rok vydání: | 2020 |
| Předmět: |
Lipopolysaccharides
Male Future studies Inflammasomes Interleukin-1beta Neurocognitive Disorders Physiology Mothers Gestational Age Pyrin domain 03 medical and health sciences Mice 0302 clinical medicine NLR Family Pyrin Domain-Containing 3 Protein Medicine Animals Receptor Biological Psychiatry Neuroinflammation 030304 developmental biology Illness Behavior 0303 health sciences business.industry Brain Inflammasome medicine.disease Mice Inbred C57BL Psychiatry and Mental health Immunity Active Animals Newborn Schizophrenia Behavior Rating Scale Gestation Female business 030217 neurology & neurosurgery Injections Intraperitoneal Immune activation medicine.drug |
| Zdroj: | Acta neuropsychiatrica. 32(6) |
| ISSN: | 1601-5215 0924-2708 |
| Popis: | Objective:To evaluate the involvement of nod-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome in schizophrenia-like behaviour in young animals exposed to maternal immune activation (MIA).Methods:To this aim, on the 15th gestational day, the females received an injection of lipopolysaccharides. When the animals completed 7, 14 and 45 postnatal days, they were killed and the whole brain was dissected for biochemical analysis. Animals with 45 postnatal days were submitted to behavioural tests of locomotor activity, social interaction and stereotyped movements.Results:It was observed that the animals presented schizophrenia-like behaviour at 45 postnatal days associated with the increase of NLRP3 inflammasome expression and IL-1β levels on 7, 14 and 45 postnatal days.Conclusion:This study shows that MIA may be associated with a schizophrenia-like behaviour. This behaviour can be induced to a neuroinflammatory profile in the brain. These evidences may base future studies on the relationship between neuroinflammation and psychiatric disorders. |
| Databáze: | OpenAIRE |
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