Nestin expression in different tumours and its relevance to malignant grade
| Autor: | Xiuming Zhang, Shu-Nong Li, Xuhui Yang, Andy Peng Xiang, Bruce T. Lahn, Caixia Xu, Xinbing Yu, Baofeng Ma, Qiuliang Wu |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Gastrointestinal Stromal Tumors Hemangiosarcoma Nerve Tissue Proteins Adenocarcinoma Biology Pathology and Forensic Medicine Immunoenzyme Techniques Nestin Intermediate Filament Proteins Neoplasms Glioma Pancreatic cancer Biomarkers Tumor medicine Humans Angiosarcoma Rhabdomyosarcoma neoplasms Aged GiST Neurooncology General Medicine Middle Aged medicine.disease digestive system diseases Neoplasm Proteins Pancreatic Neoplasms Female |
| Zdroj: | Journal of Clinical Pathology. 61:467-473 |
| ISSN: | 1472-4146 0021-9746 |
| DOI: | 10.1136/jcp.2007.047605 |
| Popis: | Background:Nestin, an intermediate filament (IF) protein, is expressed in proliferating progenitor cells of developmental and regenerating tissues, and is identified as a neuroepithelial precursor cell marker. Recently, nestin was detected in some neoplasms such as glioma, ependymoma, melanoma, rhabdomyosarcoma, gastrointestinal stromal tumour (GIST), and testicular stromal tumour. Moreover, the expression intensity of nestin exhibited significant correlation with the malignant grade of glioma.Aims:To detect the expression of nestin in different tumours and to analyse the relationship between the expression of nestin and the malignant grade of the tumours.Methods:Formalin-fixed and paraffin-embedded surgical samples of neoplastic tissues were obtained from the Department of Pathology of Sun Yat-sen University. Histological analysis and immunohistochemical staining for nestin were performed. Histoscores were analysed by semi-quantitative evaluation.Results:Nestin was expressed predominantly in the cytoplasm of angiosarcoma, pancreatic adenocarcinoma and GIST samples, and some tumour cells expressed in the nucleus. There was a statistically significant difference between the histoscore of nestin in high malignant GIST (2.2366 (0.6920)) and that in low malignant GIST (1.3783 (0.4268)) (p = 0.003); and also between that in high malignant angiosarcoma (1.9188 (0.2069)) and that in low malignant angiosarcoma (0.6474 (0.3273)) (p = 0.000). Cavernous angioma did not express nestin. The histoscore of nestin in high malignant pancreatic adenocarcinoma (7/14) was 1.1767 (0.4676), and that in low malignant pancreatic adenocarcinoma (3/8) was 0.6577 (0.0056) (no significant difference, p = 0.112).Conclusions:Results suggest that the expression of nestin may play an important role in the development of some neoplasms such as GIST and angiosarcoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|