Coronary Vasospasm Produces Reversible Perfusion Defects Observed During Adenosine Triphosphate Stress Myocardial Single‐photon Emission Computed Tomography
| Autor: | Kazuaki Chayama, Masao Yoshizumi, Tetsuya Oshima, Koichiro Okuhara, Rieko Kuwashima, Kingo Taniguchi, Yukihiro Fukuda, Kentaro Ueda, Masao Kiguchi, Hiroki Teragawa, Yukihito Higashi |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Chest Pain medicine.medical_specialty Clinical Investigations Coronary Vasospasm Coronary Angiography Coronary artery disease Adenosine Triphosphate Japan Coronary Circulation Internal medicine medicine Humans False Positive Reactions Myocardial infarction Aged Retrospective Studies Tomography Emission-Computed Single-Photon business.industry Coronary Stenosis Coronary flow reserve Vasospasm General Medicine Middle Aged medicine.disease Thallium Radioisotopes Echocardiography Case-Control Studies Heart failure Coronary vasospasm Circulatory system Exercise Test Cardiology Female Cardiology and Cardiovascular Medicine business Perfusion |
| Zdroj: | Clinical Cardiology. 31:310-316 |
| ISSN: | 1932-8737 0160-9289 |
| DOI: | 10.1002/clc.20217 |
| Popis: | Background Adenosine triphosphate stress thallium-201 single-photon emission computed tomography (ATP-SPECT) is useful for diagnosing coronary artery disease (CAD), although sometimes false positive results are observed. It has not been established whether a coronary spasm is responsible for the false positive findings during ATP-SPECT. Hypothesis We investigated whether coronary spasm is one of the factors which produces reversible defects on ATP-SPECT. Methods Eighty-six patients (mean age: 62 y; 58 men) who underwent both spasm-provocation testing by coronary angiography and ATP-SPECT, were selected for the study. Patients with coronary narrowing (>30%), myocardial infarction, or heart failure were excluded. Patients were divided into 2 groups based on whether the spasm-provocation test result was positive (vasospastic angina [VSA] group, n = 46) or negative (non-VSA group, n = 39). Results The body mass index was lower in the VSA group than in the non-VSA group (p = 0.005). On ATP-SPECT imaging, any type of reversible defect was observed more frequently in the VSA group (68%) than in the non-VSA group (36%, p = 0.0027). Logistic regression analysis demonstrated that the presence of reversible defects was one of the factors accounting for the presence of coronary vasospasm (p = 0.0022, R2 = 0.172). Conclusions The findings suggest that reversible defects on ATP-SPECT imaging are frequently present in patients with coronary vasospasm. Coronary spasm may be considered as 1 of the factors, which produce reversible defects on ATP-SPECT, observed in patients with chest symptoms and angiographically normal coronary arteries. Copyright © 2008 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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