Dynamic changes of D-dimer and neutrophil-lymphocyte count ratio as prognostic biomarkers in COVID-19

Autor: Guoxi Chen, Xing Lan, Yaling Wang, Guangwang Zeng, Min Hou, Xiaopan Li, Wenjing Ye, Di Zhang, Hai Huang, Chen Ji, Ruolin Cui, Ling Yang, Yuyang Cai, Cheng Xu, Weiwei Lu
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Neutrophils
Hospitals
Special
Severity of Illness Index
Gastroenterology
Cohort Studies
Leukocyte Count
0302 clinical medicine
030212 general & internal medicine
Mortality rate
Middle Aged
Prognosis
Survival Rate
Neutrophil-lymphocyte count ratio
COVID-19
Cox regression
Prognostic biomarker
D-dimer
Female
Coronavirus Infections
Cohort study
Adult
medicine.medical_specialty
Pneumonia
Viral
Fibrin Fibrinogen Degradation Products
03 medical and health sciences
Internal medicine
Severity of illness
medicine
Humans
Lymphocyte Count
Pandemics
Survival rate
Aged
Proportional Hazards Models
Retrospective Studies
lcsh:RC705-779
Receiver operating characteristic
Proportional hazards model
business.industry
Research
fungi
Retrospective cohort study
lcsh:Diseases of the respiratory system
030104 developmental biology
ROC Curve
business
Biomarkers
Zdroj: Respiratory Research, Vol 21, Iss 1, Pp 1-7 (2020)
Respiratory research, 21(1):169
Respiratory Research
DOI: 10.1186/s12931-020-01428-7
Popis: Background Since December 2019, the outbreak of COVID-19 caused a large number of hospital admissions in China. Many patients with COVID-19 have symptoms of acute respiratory distress syndrome, even are in danger of death. This is the first study to evaluate dynamic changes of D-Dimer and Neutrophil-Lymphocyte Count Ratio (NLR) as a prognostic utility in patients with COVID-19 for clinical use. Methods In a retrospective study, we collected data from 349 hospitalized patients who diagnosed as the infection of the COVID-19 in Wuhan Pulmonary Hospital. We used ROC curves and Cox regression analysis to explore critical value (optimal cut-off point associated with Youden index) and prognostic role of dynamic changes of D-Dimer and NLR. Results 349 participants were enrolled in this study and the mortality rate of the patients with laboratory diagnosed COVID-19 was 14.9%. The initial and peak value of D-Dimer and NLR in deceased patients were higher statistically compared with survivors (P
Databáze: OpenAIRE
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