Long-Term Safety Follow-Up of Subjects Previously Treated with Non-Replicating Retroviral Vector-Based Gene Therapies
| Autor: | Asmae Mirkou, Ramon Mohanlal, Ming Zheng, Yuhong Qiu, Kanaka Sridharan, Christopher Hunt Keir |
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| Jazyk: | angličtina |
| Předmět: |
Adult
Male 0301 basic medicine Oncology medicine.medical_specialty Genetic enhancement Genetic Vectors HIV Infections Hemophilia A X-Linked Combined Immunodeficiency Diseases Viral vector Young Adult 03 medical and health sciences Pharmacotherapy Neoplasms Internal medicine Genetics Humans Medicine Original Research Article Young adult Gene Pharmacology Medicine(all) business.industry Cancer Genetic Therapy General Medicine Middle Aged medicine.disease Human genetics Chimeric antigen receptor Retroviridae 030104 developmental biology Immunology Molecular Medicine Female business Follow-Up Studies |
| Zdroj: | Molecular Diagnosis & Therapy |
| ISSN: | 1177-1062 |
| DOI: | 10.1007/s40291-016-0229-9 |
| Popis: | Objective Our objective was to evaluate the life-long safety profile of gene therapy using retroviral (non-replicating) vectors (nRCR), or cell products in 127 subjects with hemophilia, human immunodeficiency virus (HIV), or cancer, previously treated with such gene therapy. Methods We assessed the occurrence of serious adverse events (SAEs), deaths and presence of replication competent retrovirus (RCR). Results A total of 23 subjects remained until the data cut-off date of 31 July 2013 and provided safety information of up to 18 years. Of the 104 subjects who discontinued, the primary reason was loss to follow-up (47.2 %; n = 60). The follow-up period for the 60 subjects lost to follow-up was 7–10 years. A total of 41 subjects experienced at least one SAE, and 15 subjects died. We reviewed SAEs and cause of death (none related to the active therapy), but no evidence was found for safety signals related to new malignancy or neurologic, rheumatological, autoimmune, or hematologic disorder. RCR results were negative, indicating no evidence for in vivo vector persistence. Conclusion Despite the loss of follow-up, which is the limiting factor in this long-term safety trial, the findings from this long-term follow-up study are encouraging. |
| Databáze: | OpenAIRE |
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